2-(4-[5-(三氟甲基)-2-吡啶]哌嗪)苯甲醛 | 306936-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 2-(4-[5-(三氟甲基)-2-吡啶]哌嗪)苯甲醛
• 英文名称: 2-(4-[5-(Trifluoromethyl)-2-pyridyl]piperazino)benzaldehyde
• 英文别名: 2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]benzaldehyde
• CAS: 306936-03-8
• 化学式: C₁₇H₁₆F₃N₃O
• mdl: MFCD00662543
• 分子量: 335.32
• InChiKey: IQYINUQJLSBDSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.294
• 拓扑面积：
  36.4
• 氢给体数：
  0
• 氢受体数：
  7

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  N-苄基羟胺盐酸盐 、 2-(4-[5-(三氟甲基)-2-吡啶]哌嗪)苯甲醛 生成 N-Benzyl-C-{2-[4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl]phenyl}nitrone
  参考文献：
  名称：

  Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders

  摘要：

  本发明涉及芳基、杂环芳基和双环芳基亚硝基化合物及含有这些衍生物的药物组成物。所述组成物可用于预防和/或治疗哺乳动物中的疼痛、神经退行性、自身免疫和炎症性疾病或病状。

  公开号：

  US20070275932A1

文献信息

• [EN] NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS<br/>[FR] NOUVEAUX DÉRIVÉS ARYLES SUBSTITUÉS, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS THÉRAPEUTIQUES EN TANT QU'AGENTS ANTI-VIH
  申请人：CELLVIR

  公开号：WO2010066847A1

  公开（公告）日：2010-06-17

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting virus replication and for treating viral diseases or disorders such as HIV and/or HCV infection.

  本发明涉及新型取代芳基衍生物，其制备方法以及用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。
• NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS
  申请人：Benarous Richard

  公开号：US20120022054A1

  公开（公告）日：2012-01-26

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting virus replication and for treating viral diseases or disorders such as HIV and/or HCV infection.

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。
• Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
  申请人：Cellvir

  公开号：EP2196453A1

  公开（公告）日：2010-06-16

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting integration and for treating viral diseases or disorders such as HIV.

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制整合和治疗病毒性疾病或紊乱（如艾滋病毒）的用途。
• ARYL, HETEROAROMATIC AND BICYCLIC ARYL NITRONE COMPOUNDS, PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS
  申请人：Renovis, Inc.

  公开号：EP1660011A2

  公开（公告）日：2006-05-31
• [EN] ARYL, HETEROAROMATIC AND BICYCLIC ARYL NITRONE COMPOUNDS, PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS<br/>[FR] COMPOSES DE NITRONE ARYLE BICYCLIQUES ET HETEROAROMATIQUES, PROMEDICAMENTS ET COMPOSITIONS PHARMACEUTIQUES DE CES COMPOSES, DESTINES A TRAITER DES TROUBLES CHEZ LES HUMAINS
  申请人：RENOVIS INC

  公开号：WO2005016272A2

  公开（公告）日：2005-02-24

  Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune and inflammatory diseases or conditions in mammals.