tert-Butyl 1-[(dimethylamino)carbonyl]-4-piperidinylcarbamate | 873537-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-Butyl 1-[(dimethylamino)carbonyl]-4-piperidinylcarbamate
• 英文别名: tert-Butyl 1-(dimethylcarbamoyl)piperidin-4-ylcarbamate；tert-butyl N-[1-(dimethylcarbamoyl)piperidin-4-yl]carbamate
• CAS: 873537-34-9
• 化学式: C₁₃H₂₅N₃O₃
• mdl: MFCD17014469
• 分子量: 271.36
• InChiKey: NUFLIFIOSXIFOX-UHFFFAOYSA-N

物化性质

• 沸点：
  408.0±34.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.846
• 拓扑面积：
  61.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-叔丁氧羰基氨基哌啶 、 二甲氨基甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以94%的产率得到tert-Butyl 1-[(dimethylamino)carbonyl]-4-piperidinylcarbamate
  参考文献：
  名称：

  THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY

  摘要：

  公开号：

  EP1775298B1

文献信息

• Thienopyrazole derivative having PDE7 inhibitory activity
  申请人：Daiichi Sankyo Company, Limited

  公开号：US07932250B2

  公开（公告）日：2011-04-26

  To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

  为了提供选择性抑制PDE 7的噻吩嘧啶衍生物，并因此增强细胞cAMP水平。因此，该化合物可用于治疗各种疾病，如过敏性疾病，炎症性疾病或免疫性疾病。该化合物是由以下式子（I）表示的噻吩嘧啶化合物：[其中，特别地，R1是环己基，环庚基或四氢吡喃基; R2是甲基; R3是氢原子; R4是一个基团：—CONR5R6（其中R5和R6中的任何一个是氢原子）]。
• Thienopyrazole Derivative Having PDE7 Inhibitory Activity
  申请人：Inoue Hidekazu

  公开号：US20090131413A1

  公开（公告）日：2009-05-21

  To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: —CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].

  为了提供选择性抑制PDE 7的噻唑吡啶衍生物，从而增强细胞cAMP水平。因此，该化合物可用于治疗各种疾病，如过敏性疾病、炎症性疾病或免疫性疾病。该化合物是由以下式子(I)表示的噻唑吡啶化合物：[其中，特别地，R1是环己基、环庚基或四氢吡喃基；R2是甲基；R3是氢原子；R4是一个基团：—CONR5R6（其中R5和R6中的任何一个是氢原子）]。
• Thienopyrazole derivatives having PDE7 inhibitory activity
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2433943A1

  公开（公告）日：2012-03-28

  To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: -CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

  提供选择性抑制 PDE 7 并因此提高细胞 cAMP 水平的噻吩并吡唑衍生物。因此，该化合物可用于治疗各种疾病，如过敏性疾病、炎症性疾病或免疫性疾病。该化合物是由下式（I）代表的噻吩并唑化合物： [其中，R1 特别是环己基、环庚基或四氢吡喃基；R2 是甲基；R3 是氢原子；R4 是基团：-CONR5R6（其中 R5 和 R6 中的任一个是氢原子）]。
• US7932250B2
  申请人：——

  公开号：US7932250B2

  公开（公告）日：2011-04-26
• US8901315B2
  申请人：——

  公开号：US8901315B2

  公开（公告）日：2014-12-02