2-(4-氯苯基)-3-氧代-3-苯基丙腈 | 5415-05-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 2-(4-氯苯基)-3-氧代-3-苯基丙腈
• 英文名称: 2-(4-chloro-phenyl)-3-oxo-3-phenyl-propionitrile
• 英文别名: 2-(4-Chlor-phenyl)-3-oxo-3-phenyl-propionitril；4'-Chlor-desoxybenzoin-ms-carbonsaeure-nitril；4'-Chlor-ms-cyan-desoxybenzoin；α-p-Chlorphenyl-benzoylacetonitril；Benzoyl-p-chlorphenylacetonitril；2-(4-Chlorophenyl)-3-oxo-3-phenylpropanenitrile
• CAS: 5415-05-4
• 化学式: C₁₅H₁₀ClNO
• 分子量: 255.703
• InChiKey: FMKLILXYVWBJCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-氯苯基)-3-氧代-3-苯基丙腈 在 硫酸 作用下， 生成 2-(4-chloro-phenyl)-3-oxo-3-phenyl-propionic acid amide
  参考文献：
  名称：

  von Walther; Hirschberg, Journal fur praktische Chemie (Leipzig 1954), 1903, vol. <2> 67, p. 385

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲酰腈 、 对氯苯乙腈 在 三乙胺 作用下， 生成 2-(4-氯苯基)-3-氧代-3-苯基丙腈
  参考文献：
  名称：

  Application of time-variable feedback to the input amplifier of pulse magnetic resonance spectrometers: Experimental studies

  摘要：

  Experimental research on the improvement of the sensitivity and time resolution of pulsed magnetic resonance spectrometers is discussed. It is shown that application of a time-variable feedback of a signal to the input of the receiver amplifier can decouple the "fixed" relationship between the quality factor Q and the ringdown time of the resonance system. Experiments were performed with low-frequency, radio-frequency and microwave pulse-type magnetic resonance receivers. Modifications of an S/C-band electron spin echo modulation spectrometer carried out to check the "time-variable feedback" performance are described. It is demonstrated that the application of a time-variable feedback can significantly reduce the ringdown time and improve the recovery properties of the magnetic resonance receiver system. It is also demonstrated that the time-variable feedback can improve the overall receiver sensitivity due to the fact that the working bandwidth of the resonance system can be optimized separately for the transmitting and the receiving mode. Signal values could be increased at least three times and the signal-to-noise ratio about 1.5-2 times. The largest improvement is achieved with the initially overcoupled resonator. Experimental spectra of test samples for different settings of the time-variable feedback are shown.

  DOI：

  10.1007/bf03166126

文献信息

• Synthesis of 1,2-Diketones from β-Keto Nitriles via a Protection-Oxidative-Decyanation-Deprotection Protocol
  作者：Yunfei Du、Kang Zhao、Yu Liu、Xiliu Yun、Daisy Zhang-Negrerie、Jianhui Huang

  DOI：10.1055/s-0030-1260156

  日期：2011.9

  were prepared from β-keto nitriles via a three-step protocol including the protection of the ketones with methoxyamine, oxidative decyanation, and microwave-assisted deprotection in the final step. This approach provides a novel and efficient access to a wide scope of symmetric and unsymmetric 1,2-diketones using molecular oxygen as the oxidant in the decyanation process. β-keto nitriles - oxygen - oxidative

  通过三步方案从β-酮腈制备了各种1,2-二酮，包括在最后一步用甲氧基胺保护酮，氧化脱氰和微波辅助脱保护。这种方法在脱氰过程中使用分子氧作为氧化剂，提供了一种新颖而有效的途径，可以广泛地使用对称和不对称的1,2-二酮。 β-酮腈-氧气-氧化脱氰-微波-1,2-二酮
• Studies on heterocyclic chemistry. Part X. Synthesis of aziridin-2-ylphosphonates by the thermally induced isomerization of isoxazoles in trialkyl phosphites. A related reaction of 2H-azirine
  作者：Tarozaemon Nishiwaki、Toshinori Saito

  DOI：10.1039/j39710003021

  日期：——

  The reactions of isoxazoles and of 2H-azirines with trialkyl phosphite have been studied. 5-Amino-3-arylisoxazoles and 3-aryl-2H-azirine-2-carboxamides afford aziridin-2-ylphosphonates whereas 5-methoxy-3-phenylisoxazole gives an aziridine dimer which has a phosphonyl group at C-2. 5-Amino-3,4-diphenylisoxazole, 2,3-diphenyl-2H-azirine-2-carboxamide, and related compounds produce Δ4-oxazolin-2-ylphosphonates

  已经研究了异恶唑和2 H-叠氮基与亚磷酸三烷基酯的反应。5-氨基-3-芳基异恶唑和3-芳基-2- ħ -azirine -2-甲酰胺，得到氮丙啶-2- ylphosphonates而-5-甲氧基-3-苯基异恶唑给出了在C-2具有膦酰基氮丙啶二聚体。5-氨基-3,4- diphenylisoxazole，2,3-二苯基-2- ħ -azirine -2-甲酰胺，和相关化合物产生Δ 4 -oxazolin -2- ylphosphonates通过氮丙啶-2- ylphosphonates。这些反应的机理可以通过亚磷酸三烷基酯对2 H-叠氮基的C N键的亲核攻击来解释。
• 2,4-Diaminopyrimidines as Antimalarials. III. 5-Aryl Derivatives
  作者：Peter B. Russell、George H. Hitchings

  DOI：10.1021/ja01152a060

  日期：1951.8
• v. Walther; Hirschberg, Journal fur praktische Chemie (Leipzig 1954), 1903, vol. <2> 67, p. 383
  作者：v. Walther、Hirschberg

  DOI：——

  日期：——
• von Walther; Hirschberg, Journal fur praktische Chemie (Leipzig 1954), 1903, vol. <2> 67, p. 378
  作者：von Walther、Hirschberg

  DOI：——

  日期：——