1-[(2R,4S,5R)-5-[2-[[(2R,3S,5R)-2-[2-[[(2R,3S,5R)-2-[2-[[(2R,3S,5R)-2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]methylsulfanyl]ethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]methylsulfanyl]ethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]methylsulfanyl]ethyl]-4-(sulfanylmethyl)oxolan-2-yl]pyrimidine-2,4-dione 、 2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[[bis(4-methoxyphenyl)-phenylmethyl]sulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethyl methanesulfonate 在
1,8-二氮杂双环[5.4.0]十一碳-7-烯 、
1,4-dithio-erythritol 作用下,
以
四氢呋喃 、
甲醇 为溶剂,
反应 24.08h,
以55%的产率得到1-[(2R,4S,5R)-5-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethyl]-4-[2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[2-[(2R,3S,5R)-3-[[bis(4-methoxyphenyl)-phenylmethyl]sulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]ethylsulfanylmethyl]oxolan-2-yl]pyrimidine-2,4-dione