N,N-diethyl-N'-[(trifluoromethyl)thio]pentane-1,4-diamine | 1045821-64-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: N,N-diethyl-N'-[(trifluoromethyl)thio]pentane-1,4-diamine
• 英文别名: 1-N,1-N-diethyl-4-N-(trifluoromethylsulfanyl)pentane-1,4-diamine
• CAS: 1045821-64-4
• 化学式: C₁₀H₂₁F₃N₂S
• 分子量: 258.351
• InChiKey: HGUDCFGRADAXNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (三氟甲基)三甲基硅烷 、 2-氨基-5-二乙基氨基戊烷 在 二乙胺基三氟化硫 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以74%的产率得到N,N-diethyl-N'-[(trifluoromethyl)thio]pentane-1,4-diamine
  参考文献：
  名称：

  Synthesis of Trifluoromethanesulfinamidines and -sulfanylamides

  摘要：

  Fluorinated moieties constitute important substituents used in many applications to modify the properties of molecules. The action of DAST onto Ruppert's rea gent yields to a not isolable intermediate that can then react with various primary amines to give trifluoromethanesulfinamidines and trifluoromethanesulfanylamides. Such compounds were unknown until now and constitute interesting new families of fluorinated molecules.

  DOI：

  10.1021/jo8018544

文献信息

• Synthesis of Trifluoromethanesulfinamidines and -sulfanylamides
  作者：Aurélien Ferry、Thierry Billard、Bernard R. Langlois、Eric Bacqué

  DOI：10.1021/jo8018544

  日期：2008.12.5

  Fluorinated moieties constitute important substituents used in many applications to modify the properties of molecules. The action of DAST onto Ruppert's rea gent yields to a not isolable intermediate that can then react with various primary amines to give trifluoromethanesulfinamidines and trifluoromethanesulfanylamides. Such compounds were unknown until now and constitute interesting new families of fluorinated molecules.