3,6-dichloro-4-[4-(2-p-methylphenoxy-ethyl)-piperazin-1-yl]pyridazine | 921769-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3,6-dichloro-4-[4-(2-p-methylphenoxy-ethyl)-piperazin-1-yl]pyridazine
• 英文别名: 3,6-Dichloro-4-{4-[2-(4-methylphenoxy)ethyl]piperazin-1-yl}pyridazine；3,6-dichloro-4-[4-[2-(4-methylphenoxy)ethyl]piperazin-1-yl]pyridazine
• CAS: 921769-44-0
• 化学式: C₁₇H₂₀Cl₂N₄O
• 分子量: 367.278
• InChiKey: YVHHKWBXYFAWBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  41.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors
  申请人：Li Song

  公开号：US20080269232A1

  公开（公告）日：2008-10-30

  The present invention relates to substituted pyridazinylamine derivatives of the formula I or pharmaceutically acceptable salts or hydrates thereof, wherein the substituents are defined as in the description, their preparation process, pharmaceutical compositions comprising them, and uses of the said compounds as picorna virus inhibitors for prevention and/or treatment of diseases caused by picorna viruses.

  本发明涉及式I的取代吡啶嗪胺衍生物或其药学上可接受的盐或水合物，其中取代基如描述中所定义，它们的制备过程，含有它们的药物组合物，以及作为小肠病毒抑制剂用于预防和/或治疗由小肠病毒引起的疾病的所述化合物的用途。
• Pyrazole Compounds for Controlling Invertebrate Pests
  申请人：Soergel Sebastian

  公开号：US20130253012A1

  公开（公告）日：2013-09-26

  The present invention relates to a method for controlling invertebrate pests, in particular arthropod pests and nematodes, by using pyrazole compounds of formula I and the salts thereof, the tautomers thereof, the N-oxides thereof and the salts of the tautomers or N-oxides thereof, wherein X is N or CH, Y is N or CH, Z is N or CH, provided that either only one of X, Y and Z is N or only two adjacent groups of X, Y and Z are N; and wherein Q is a bivalent 5- or 6-membered carbocyclic radical or a 5- or 6-membered heterocyclic radical having one heteroatom moiety which is selected from the group consisting of O, S, N or N—R QN as ring member and 0, 1 or 2 further heteroatom moieties N as ring members, wherein 0, 1, 2 or 3 of the ring members that are carbon atoms may carry a radical R Q , provided that the pyrazole radical and the 6-membered heteroaromatic radical are bound in ortho- or meta-position of Q with respect to each other, if Q is a 6-membered radical; and wherein R A , if present, is C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl or the like; n is 0, 1 or 2; R N is C 1 -C 3 -alkyl, C 1 -C 2 -haloalkyl, C 1 -C 2 -alkoxy-C 1 -C 2 -alkyl or the like; R t and R u are independently of each other selected from hydrogen, methyl and the like; R QN is hydrogen, C 1 -C 4 -alkyl or the like; R Q is hydrogen, halogen, C 1 -C 4 -alkyl or the like. The present invention further relates to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material, comprising at least one compound of formula I, their salts or N-oxides, and to pyrazole compounds of formula I.

  本发明涉及一种使用式I的吡唑化合物及其盐、互变异构体、N-氧化物及其互变异构体或N-氧化物的盐，控制无脊椎动物害虫，特别是节肢动物害虫和线虫的方法，其中X为N或CH，Y为N或CH，Z为N或CH，只有X、Y和Z中的一个是N或仅有相邻的两个X、Y和Z中的一个是N；Q为二价的5-或6-成员的碳环或一个5-或6-成员的杂环基团，其中一个杂原子基团被选择为O、S、N或N-RQ，作为环成员，0、1或2个进一步的杂原子基团N作为环成员，其中0、1、2或3个是碳原子的环成员可能携带一个基团RQ，只要吡唑基团和6-成员杂环芳基团在Q的正交或间位于彼此相对位置，如果Q是6-成员基团；RA如果存在，则为C1-C3烷基、C1-C3卤代烷基或类似物；n为0、1或2；RN为C1-C3烷基、C1-C2卤代烷基、C1-C2-烷氧基-C1-C2-烷基或类似物；Rt和Ru独立地选择自氢、甲基等；RQN为氢、C1-C4烷基或类似物；RQ为氢、卤素、C1-C4烷基或类似物。本发明还涉及一种保护植物繁殖材料和/或从中生长的植物的方法，包括至少一种式I化合物、它们的盐或N-氧化物，以及式I的吡唑化合物的植物繁殖材料。
• PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：EP1900735B1

  公开（公告）日：2012-06-13
• PYRAZOLE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS
  申请人：BASF SE

  公开号：EP2648518A2

  公开（公告）日：2013-10-16
• US8076339B2
  申请人：——

  公开号：US8076339B2

  公开（公告）日：2011-12-13