2-(benzofuran-4-yloxy)-2-methyl-propionamide | 51817-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-(benzofuran-4-yloxy)-2-methyl-propionamide
• 英文别名: 2-(1-Benzofuran-4-yloxy)-2-methylpropanamide
• CAS: 51817-41-5
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: RCWZTTKGYCIJJH-UHFFFAOYSA-N

物化性质

• 沸点：
  402.2±25.0 °C(Predicted)
• 密度：
  1.213±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(benzofuran-4-yloxy)-2-methyl-propionamide 在 盐酸 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 1-苯并呋喃-4-胺
  参考文献：
  名称：

  Facile Entry to 4‐ and 5‐Hydroxybenzofuran and to Their Amino Derivatives

  摘要：

  An innovative one-step procedure for the synthesis of 4-hydroxybenzofuran and an improved synthesis of 5-hydroxybenzofuran is reported. Such compounds were also transformed into their amino derivatives via Smiles rearrangement with good to high overall yields.

  DOI：

  10.1080/00397910600634118
• 作为产物：
  描述：

  苯并呋喃-4-醇 、 2-溴异丁酰胺 在 1,4-二氧六环 、 sodium hydride 作用下， 反应 6.0h， 以60%的产率得到2-(benzofuran-4-yloxy)-2-methyl-propionamide
  参考文献：
  名称：

  Facile Entry to 4‐ and 5‐Hydroxybenzofuran and to Their Amino Derivatives

  摘要：

  An innovative one-step procedure for the synthesis of 4-hydroxybenzofuran and an improved synthesis of 5-hydroxybenzofuran is reported. Such compounds were also transformed into their amino derivatives via Smiles rearrangement with good to high overall yields.

  DOI：

  10.1080/00397910600634118

文献信息

• Facile Entry to 4‐ and 5‐Hydroxybenzofuran and to Their Amino Derivatives
  作者：Carlo Bonini、Graziella Cristiani、Maria Funicello、Licia Viggiani

  DOI：10.1080/00397910600634118

  日期：2006.6

  An innovative one-step procedure for the synthesis of 4-hydroxybenzofuran and an improved synthesis of 5-hydroxybenzofuran is reported. Such compounds were also transformed into their amino derivatives via Smiles rearrangement with good to high overall yields.