4-methoxy-naphthalene-1-sulfonic acid amide | 95834-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-methoxy-naphthalene-1-sulfonic acid amide
• 英文别名: 4-Methoxy-naphthalin-1-sulfonsaeure-amid；4-Methoxynaphthalene-1-sulfonamide
• CAS: 95834-50-7
• 化学式: C₁₁H₁₁NO₃S
• mdl: MFCD01809919
• 分子量: 237.279
• InChiKey: ZQHDRZCQJLIEIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  77.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-甲氧基萘 在 chlorosulphuric acid 、 氯仿 作用下， 生成 4-methoxy-naphthalene-1-sulfonic acid amide
  参考文献：
  名称：

  Identification of Organic Compounds. III. Chlorosulfonic Acid as a Reagent for the Characterization of Aromatic Ethers^1,2

  摘要：

  DOI：

  10.1021/ja01860a049

文献信息

• [EN] NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS DE N-ACYL-ARYLSULFONAMIDE UTILISÉS EN TANT QU'INHIBITEURS D'AMINOACYL-ARNT SYNTHÉTASE
  申请人：LATVIAN INST ORGANIC SYNTHESIS

  公开号：WO2016129983A1

  公开（公告）日：2016-08-18

  The present invention relates to novel N-acyl-diarysulfonamides acting as inhibitors of bacterial aminoacyl-tRNA synthetase. These can be used as medicines or as constituent of medicines for the treatment of bacterial infections.

  本发明涉及作为细菌氨酰-tRNA合成酶抑制剂的新型N-酰基二芳基磺酰胺。这些可以用作药物或药物成分，用于治疗细菌感染。
• N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors
  申请人：Oxford Drug Design Limited

  公开号：US11072581B2

  公开（公告）日：2021-07-27

  The present invention relates to novel N-acyl-diarysulfonamides acting as inhibitors of bacterial aminoacyl-tRNA synthetase. These can be used as medicines or as constituent of medicines for the treatment of bacterial infections.

  本发明涉及作为细菌氨基酰-tRNA 合成酶抑制剂的新型 N-酰基二亚磺酰胺类化合物。这些药物可用作治疗细菌感染的药物或药物成分。
• NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS
  申请人：LATVIAN INSTITUTE OF ORGANIC SYNTHESIS

  公开号：US20180022696A1

  公开（公告）日：2018-01-25

  The present invention relates to novel N-acyl-diarysulfonamides acting as inhibitors of bacterial aminoacyl-tRNA synthetase. These can be used as medicines or as constituent of medicines for the treatment of bacterial infections.
• [EN] KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS<br/>[FR] INHIBITEURS DE KINASES CAPABLES DE RENFORCER LA SENSIBILITÉ D'AGENTS PATHOGÈNES BACTÉRIENS AUX ANTIBIOTIQUES DE LA FAMILLE DES B-LACTAMINES
  申请人：SEATTLE CHILDREN S RES INST

  公开号：WO2013066469A2

  公开（公告）日：2013-05-10

  Staphylococcus aureus are gram-positive bacteria that are currently the leading cause of invasive infections in humans. While antibiotic therapy is currently used to treat S. aureus infections, the emergence of antibiotic resistant strains such as those resistant to methicillan are rapidly exhausting treatment options. Disclosed herein are methods and compositions for increasing the sensitivity of bacterial pathogens to β-lactam antibiotics. Also disclosed herein are genes involved in modulating antibiotic resistance which serve as novel targets for treatments aimed at inhibiting antibiotic resistant bacterial pathogens. Also disclosed herein are kinase inhibitors which demonstrate superior activity in sensitizing bacterial pathogens to β-lactam antibiotics.