thiophosphorochloridic acid O-ethyl ester O'-isopropyl ester | 51162-51-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 英文名称: thiophosphorochloridic acid O-ethyl ester O'-isopropyl ester
• 英文别名: chlorothiophosphoric acid O-ethyl ester-O'-isopropyl ester；Chlorothiophosphorsaeure-O-aethylester-O'-isopropylester；O-ethyl-O-(1-methyl-ethyl)phosphorochloridothioate；O-ethyl O-isopropyl Chlorothiophosphate；Monothiophosphorsaeure-O-ethyl-O-isopropylester-chlorid；O-Aethyl-O-isopropylthiophosphorylchlorid；Phosphorochloridothioic acid, O-ethyl O-(1-methylethyl) ester；chloro-ethoxy-propan-2-yloxy-sulfanylidene-λ5-phosphane
• CAS: 51162-51-7
• 化学式: C₅H₁₂ClO₂PS
• 分子量: 202.642
• InChiKey: YFCPDTHWTNVJIV-UHFFFAOYSA-N

物化性质

• 沸点：
  84-85 °C(Press: 10 Torr)
• 密度：
  1.1561 g/cm3
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  thiophosphorochloridic acid O-ethyl ester O'-isopropyl ester 在 氢氧化钾 作用下， 生成 thiophosphoric acid O-ethyl ester-S-(2-ethylsulfanyl-ethyl ester)-O'-isopropyl ester
  参考文献：
  名称：

  DE1083809

  摘要：

  公开号：
• 作为产物：
  描述：

  O-isopropyl phosphorodichloridothioate 、 magnesium ethylate 在 乙醇 作用下， 生成 thiophosphorochloridic acid O-ethyl ester O'-isopropyl ester
  参考文献：
  名称：

  Mel'nikow et al., Zhurnal Obshchei Khimii, 1957, vol. 27, p. 1905; engl. Ausg. S. 1967

  摘要：

  DOI：

文献信息

• Phosphoryl hydrazine insecticides .
  申请人：ROHM AND HAAS COMPANY

  公开号：EP1004589A1

  公开（公告）日：2000-05-31

  This invention relates to a new class of phosphoryl hydrazine compounds which are useful as insecticides, acaricides, anthelmintics, and nematocides, compositions containing the compounds, and methods for their use. This invention also relates to methods to produce such compounds.

  本发明涉及一种新型的磷酸酰肼类化合物，其可用作杀虫剂、杀螨剂、驱虫剂和线虫剂，包含该化合物的组合物以及其使用方法。本发明还涉及生产这种化合物的方法。
• Dithiopyrophosphates and their use as pesticides
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0437335A1

  公开（公告）日：1991-07-17

  Dithiopyrophosphates and compositions containing dithiopyrophosphates are useful as pesticides, particularaly against soil insects such as corn rootworm.

  Dithiopyrophosphates和含有Dithiopyrophosphates的组合物作为杀虫剂很有用，特别是对付土壤昆虫，如玉米根蠕虫。
• Molecular Pharmacological Studies on Drug-Receptor Complexes System in Drug Action. IV. Relationship between Anticholinergic and Anticholinesterase Activities of Organophosphoryl Choline Derivatives based on their Chemical Structure
  作者：Masayasu Kimura、Isamu Saikawa

  DOI：10.1248/cpb.12.159

  日期：——

  To clarify the relationship between anticholinergic and anticholinesterase (anti-ChE) activities on the basis of chemical structure, nineteen organophosphoryl choline derivatives [chemical formula] were synthesized. Curare-like, atropine-like and anticholinesterase actions of these compounds were tested to screen. The experimental results were as follows : 1) Curare-like and atropine-like actions were both studied by Magnus method, observing their effect on rectus abdominis of frog and on intestines of white mice. Anti-ChE action on enzyme preparation from rabbit serum was tested by using Warburg's manometric method. 2) As to the basic structure of various organophosphoryl choline derivatives, curarelike action was increased in the following order of magnitude ; [chemical formula]. The R radicals increased the potency in the following order ; [chemical formula] and as for quaternary ammonium salts of derivatives, bromides were more potent than iodides. From these compounds it was found that four derivatives of NP-244 (I), NP-245 (I), NP-244pC (I) and NP244pB (I) was more potent than curare. 3) On the atropine-like action of organophosphoryl choline derivatives, the relation between their structure and potency was found to have the same tendency as in the case of curare-like action, but all of these derivative were weaker than that of atropine. 4) On the anti-ChE action of organophosphoryl choline, the basic structures increased its potency in the following order ; [chemical formula], but the change in R radicals did not always increase the potency of their curare-like action. All of these derivatives were weaker than neostigmine. 5) The relationship between curare-like and atropine-like actions and between curare-like and anti-ChE actions were discussed with the selective indexes calculated from experimental results. Some of thionothiol-phosphate have both curare-like and ChE activity, and its curare-like action is little antagonized by neostigmine. From these facts, it was suggested that acetylcholine receptor was perhaps different from ChE.

  羧胺。
• 2-Alkyl-5-pyrimidines
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0097451A1

  公开（公告）日：1984-01-04

  Novel 2-alkyl-5-halopyrimidines, e.g., 5-chloro-2-(1,1-dimethylethyl)pyrimidine, which are useful as intermediates in the preparation of, e.g., 0,0-diethyl 0-(2-(1,1-dimethylethyl)-5-pyrimidinyl) phosphorothioate which is useful as an insecticide against corn rootworm and cutworm.

  新型 2-烷基-5-卤代嘧啶，如 5-氯-2-(1,1-二甲基乙基)嘧啶，可用作制备 0,0-二乙基 0-(2-(1,1-二甲基乙基)-5-嘧啶基)硫代磷酸酯的中间体，该硫代磷酸酯可用作防治玉米根虫和切割虫的杀虫剂。
• Verfahren zur Herstellung von (Thiono)Phosphorsäureestern
  申请人：BAYER AG

  公开号：EP0207412A2

  公开（公告）日：1987-01-07

  Die Erfindung betrifft eine neues Verfahren zur Herstellung von (Thiono)Phosphorsäureestern der Formel (I) In welcher X für Sauerstoff oder Schwefel steht, R und R' gleich oder verschieden sind und fur̈ Alkyl stehen und R2 für gegebenenfalls substituiertes Aryl oder für gegebenenfalls substituiertes Hetaryl mit mindestens einem Stickstoffatom steht, durch die Umsetzung von Hydroxy-Derivaten der Formel (II) R' die oben angegebene Bedeutung hat, oder deren antsprechenden Ammonium-, Alkali- oder Erdalkalimetallsaize, mit (Thiono) Phosphorsäurehalogeniden der Formel (III) In weicher und X, R und R' die oben angegebenen Bedeutungen haben Hal für Halogen, Insbesondere Chlor oder Brom, steht, in Gegenwart eines bicyclischen organischen Amins als Katalysator, gegebenanfalls in Gegenwart von Säureakzeptoren, und In Gegenwart eines Verdünnungsmittels bei Temperaturen zwischen 0 und 120°C. Als bicyclische organische Amine kommen bevorzugt bicyclische Amine mit 1 oder 2 Brückenkopf-Stickstoffatomen, vorzugswiese 1,4-Diazebicyclo-(2,2,2)-octan (DABCO) und Chinuclidin In Frage. Besonders bevorzugt ist DABCO.

  本发明涉及一种制备式 (I) （硫代）磷酸酯的新工艺。 其中 X 是氧或硫、 R和R'相同或不同，代表烷基，以及 R2 代表至少有一个氮原子的任选取代的芳基或任选取代的庚基，通过与式 (II) 的羟基衍生物反应制得 R'具有上述含义，或其相应的铵、碱金属或碱土金属盐与式 (III) 的（硫代）磷酸卤化物反应 在软 X、R 和 R' 具有上述含义 Hal 是卤素，特别是氯或溴，在双环有机胺作为催化剂存在下，可选择在酸接受体存在下，在稀释剂存在下，温度在 0 至 120°C 之间。 首选的双环有机胺是具有 1 个或 2 个桥头氮原子的双环胺，最好是 1,4-二氮双环-(2,2,2)-辛烷 (DABCO) 和奎宁环。DABCO 尤为可取。