benzo[1,2,5]thiadiazole-5-sulfonic acid | 89324-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻二唑类
• 英文名称: benzo[1,2,5]thiadiazole-5-sulfonic acid
• 英文别名: Benzo[1,2,5]thiadiazol-5-sulfonsaeure；Benz-2,1,3-thiodiazol-sulfonsaeure-(5)；2,1,3-Benzothiadiazole-5-sulfonic acid；2,1,3-benzothiadiazole-5-sulfonic acid
• CAS: 89324-25-4
• 化学式: C₆H₄N₂O₃S₂
• 分子量: 216.241
• InChiKey: OIISEIXGENSCJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,4-二氨基苯磺酸 、 N-亚磺酰苯胺 在 苯胺 作用下， 生成 benzo[1,2,5]thiadiazole-5-sulfonic acid
  参考文献：
  名称：

  Chalezkii et al., Doklady Akademii Nauk SSSR, 1956, vol. 106, p. 88,89

  摘要：

  DOI：

文献信息

• Substituted indole sulfonamide compounds their preparation and use as medicaments
  申请人：Laboratorios Del. Dr. Esteve, S.A.

  公开号：EP2149573A1

  公开（公告）日：2010-02-03

  The present invention relates to indole sulfonamide compounds of general formula (I), a process for their preparation, a medicament comprising these compounds and the use of the indole sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.

  本发明涉及一般式(I)的吲哚磺胺化合物，其制备方法，包含这些化合物的药物以及利用吲哚磺胺化合物制备用于5-HT6受体调节和相关疾病治疗的药物。
• [EN] BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY<br/>[FR] COMPOSES DE BISARYLSULFONAMIDE ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：CYCLACEL LTD

  公开号：WO2004005278A1

  公开（公告）日：2004-01-15

  The present invention relates to the use of bisarylsulfonamide compounds of formula (I) wherein W is a CI-5 branched or unbranched alkyl group or a C2-5 alkenyl group; nis0or1; R1 is H, a C, 1-8 branched or unbranched alkyl group, a C2-8 alkenyl group, or an aryl or aralkyl group; Ar1 is a substituted thienyl, furyl, pyrrolyl, imidazothiazolyl, thiazolyl, pyridyl or phenyl group; and Ar2 is a substituted phenyl, indolyl or benzoimidazolyl group; in the preparation of a medicament for treating proliferative disorders. Further aspects of the invention relate to compounds of formula (I), pharmaceutical compositions thereof, and an assay for determining binding to HDM2.

  本发明涉及使用公式（I）中的双芳基磺酰胺化合物，其中W是CI-5支链或直链烷基或C2-5烯基基团；n为0或1；R1为H，C1-8支链或直链烷基，C2-8烯基基团，或芳基或芳基烷基团；Ar1为取代噻吩基，呋喃基，吡咯基，咪唑硫唑基，噻唑基，吡啶基或苯基；Ar2为取代苯基，吲哚基或苯并咪唑基团，在制备用于治疗增殖性疾病的药物方面。本发明的其他方面涉及公式（I）的化合物，其制药组合物以及用于确定与HDM2结合的测定方法。
• [EN] SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS<br/>[FR] FORMES SOLIDES DE SULFONAMIDES ET D'ACIDES AMINÉS
  申请人：PLEXXIKON INC

  公开号：WO2010129570A1

  公开（公告）日：2010-11-11

  Solid forms of phenyl sulfonamide compounds of formula (I) active on protein kinases, including Raf protein kinases, are described, as well as methods of using such solid forms to treat diseases and conditions associated with activity of protein kinases, e.g. Raf protein kinases, including pain, polycystic kidney disease, melanoma and colorectal cancer.

  本文描述了公式（I）的苯基磺酰胺化合物的固体形式，其在蛋白激酶中具有活性，包括Raf蛋白激酶，以及使用这些固体形式治疗与蛋白激酶活性相关的疾病和病况的方法，例如疼痛、多囊肾病、黑色素瘤和结直肠癌。
• SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS
  申请人：Visor Gary Conard

  公开号：US20120122860A1

  公开（公告）日：2012-05-17

  Solid forms of phenyl sulfonamide compounds of formula (I) active on protein kinases, including Raf protein kinases, are described, as well as methods of using such solid forms to treat diseases and conditions associated with activity of protein kinases, e.g. Raf protein kinases, including pain, polycystic kidney disease, melanoma and colorectal cancer.

  本文描述了公式（I）的苯基磺酰胺化合物的固态形式，这些化合物对蛋白激酶具有活性，包括Raf蛋白激酶，并描述了使用这些固态形式治疗与蛋白激酶活性相关的疾病和病况的方法，例如疼痛，多囊肾病，黑色素瘤和结肠直肠癌。
• Bisarylsulfonamide compounds and their use in cancer therapy
  申请人：Wang Shudong

  公开号：US20050215548A1

  公开（公告）日：2005-09-29

  The present invention relates to the use of bisarylsulfonamide compounds of formula I wherein W is a C 1-5 branched or unbranched alkyl group or a C 2-5 alkenyl group; n is 0 or 1; R 1 is H, a C 1-8 branched or unbranched alkyl group, a C 2-8 alkenyl group, or an aryl or aralkyl group; Ar 1 is a substituted thienyl, furyl, pyrrolyl, imidazothiazolyl, thiazolyl, pyridyl or phenyl group; and Ar 2 is a substituted phenyl, indolyl or benzoimidazolyl group; in the preparation of a medicament for treating proliferative disorders. Further aspects of the invention relate to compounds of formula I, pharmaceutical compositions thereof, and an assay for determining binding to HDM2.

  本发明涉及式 I 双芳磺酰胺化合物的用途 其中 W 是 C 1-5 支链或未支链烷基或 C 2-5 烯基；n 为 0 或 1； R 1 是 H、C 1-8 支链或未支链烷基、C 2-8 烯基、芳基或芳烷基； Ar 1 是取代的噻吩基、呋喃基、吡咯基、咪唑噻唑基、噻唑基、吡啶基或苯基；以及 Ar 2 是取代的苯基、吲哚基或苯并咪唑基；用于制备治疗增生性疾病的药物。本发明的其他方面涉及式 I 的化合物、其药物组合物以及确定与 HDM2 结合的检测方法。