5,6-Dichlorobenzofuran | 128852-82-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 5,6-Dichlorobenzofuran
• 英文别名: 5,6-dichloro-1-benzofuran
• CAS: 128852-82-4
• 化学式: C₈H₄Cl₂O
• 分子量: 187.02
• InChiKey: MCHGBWHBBDJKJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES<br/>[FR] INHIBITEURS DE LA GLUCOSYLCÉRAMIDE SYNTHASE POUR LE TRAITEMENT DE MALADIES
  申请人：BIOMARIN PHARM INC

  公开号：WO2015042397A1

  公开（公告）日：2015-03-26

  Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

  本文描述了一种I式化合物，制备这种化合物的方法，含有这种化合物的药物组合物和药物，以及使用这种化合物治疗或预防与葡萄糖酰胺合成酶（GCS）相关的疾病或症状的方法。
• Hydantoin derivatives
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP0355827A2

  公开（公告）日：1990-02-28

  The present invention relates to hydantoin derivatives, represented by the formula (I): and non-toxic salts, solvates and solvates of non-toxic salts thereof; wherein q represents a mono- or a fused heterocyclic group which may be substituted by one or more substituents which are same or different and selected from a group consisting of a halogen atom, an alkyl group, a nitro group, a cyano group, an optionally protected carboxy group, an optionally protected carboxymethyl group, a halogenated alkyl group, an alkylthio group, an alkylcarbonyl group, an alkoxy group, an alkylsulfinyl group, an alkylsulfonyl group, an optionally protected hydroxy group, an optionally protected amino group, a carbamoyl group and a phenyl group, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and intermediate compounds in the synthesis of said hydantoin derivatives.

  本发明涉及由式(I)表示的海因衍生物： 及其无毒盐、溶剂和无毒盐的溶剂；其中 q 代表可被一个或多个相同或不同的取代基取代的单杂环基团或融合杂环基团，这些取代基团选自卤素原子、烷基、硝基、氰基、受任选保护的羧基、受任选保护的羧甲基、卤代烷基、烷硫基、烷基羰基、烷氧基烷基亚磺酰基、烷基磺酰基、任选受保护的羟基、任选受保护的氨基、氨基甲酰基和苯基，生产所述海因衍生物的工艺，含有至少一种所述海因衍生物作为醛糖还原酶抑制剂的药物组合物，以及合成所述海因衍生物的中间化合物。
• Glucosylceramide synthase inhibitors for the treatment of diseases
  申请人：BIOMARIN PHARMACEUTICAL INC.

  公开号：US10227323B2

  公开（公告）日：2019-03-12

  Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

  本文描述了式 I 的化合物、制造此类化合物的方法、含有此类化合物的药物组合物和药物，以及使用此类化合物治疗或预防与葡萄糖酰胺合成酶 (GCS) 相关的疾病或病症的方法。
• Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
  申请人：Janssen Pharmaceutica NV

  公开号：US10246454B2

  公开（公告）日：2019-04-02

  The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

  本发明涉及式 (I) 的新型取代吡啶-哌嗪酮衍生物 其中 R1、R2、R3、R4、R5、L、Z 和 X 具有权利要求中定义的含义。根据本发明的化合物可用作γ 分泌酶调节剂。本发明进一步涉及制备这种新型化合物的工艺、包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
• NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2945944B1

  公开（公告）日：2016-11-09