ethoxy-bis-(dimethylamino)-methane | 5815-07-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 原羧酸衍生物
• 英文名称: ethoxy-bis-(dimethylamino)-methane
• 英文别名: Bis(dimethylamino)ethoxy-methan；bis-(dimethylamino)-ethoxy methane；ethoxy-bis(dimethylamino)methane；Bis--ethoxy-methan；Bis-dimethylamino-aethoxy-methan；Ethoxy-bis-dimethylamino-methan；1-ethoxy-N,N,N',N'-tetramethylmethanediamine
• CAS: 5815-07-6
• 化学式: C₇H₁₈N₂O
• 分子量: 146.233
• InChiKey: ATIJWZXWXNXVOY-UHFFFAOYSA-N

物化性质

• 沸点：
  140.7±20.0 °C(Predicted)
• 密度：
  0.884±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  ethoxy-bis-(dimethylamino)-methane 以 乙腈 为溶剂， 以96.7%的产率得到反-3-(二甲氨基)丙烯腈
  参考文献：
  名称：

  2-(arylimino-methyl)-3-dialkylaminoacrylonitriles, a process for their

  摘要：

  2-(芳基亚胺甲基)-3-二烷基氨基丙烯腈可以通过.beta.-苯基丙烯腈与正-甲酰胺反应得到。它们适用于制备4-氨基-5-亚胺甲基-2-嘧啶或4-氨基-5-甲酰基-2-嘧啶的起始物质。

  公开号：

  US05629441A1
• 作为产物：
  描述：

  N,N,N,N-tetramethyldiamino ethoxycarbonium tetrafluoroborate 在 硼酸三甲酯 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 ethoxy-bis-(dimethylamino)-methane 、 N,N-二甲基甲酰胺二乙基缩醛
  参考文献：
  名称：

  Kantlehner, Willi; Stieglitz, Ruediger; Hauber, Michael, Journal fur Praktische Chemie (Weinheim), 2000, vol. 342, # 3, p. 256 - 268

  摘要：

  DOI：

文献信息

• 3-Vinyl-cephalosporin derivatives
  申请人：Rhone-Poulenc Industries

  公开号：US04307233A1

  公开（公告）日：1981-12-22

  Novel 3-vinyl-cephalosporin derivates of the general formula ##STR1## in the bicyclooct-2-ene or bicyclooct-3-ene form, in which R.sub.1 is a protective radical or is a radical of the general formula ##STR2## in which R.sub.5 is hydrogen, alkyl, vinyl or cyanomethyl, or a protective radical, and R.sub.6 is hydrogen or a protective radical, and R.sub.2 is a protective radical or an enzymatically removable radical, or R.sub.1 is an acyl radical, which may carry various substituents, and R.sub.2 represents a protective radical, and R.sub.3 and R.sub.4, which are identical or different, represent alkyl (optionally substituted by hydroxyl, alkoxy, amino, alkylamino or dialkylamino) or phenyl, or form, together with the nitrogen atom, a saturated 5-membered or 6-membered heterocyclic ring optionally containing another hetero-atom, their E- and Z-forms and their mixtures, are useful as intermediates for the preparation of 3-thiovinyl cephalosporins useful as antibacterial agents.

  具有通式##STR1##的新型3-乙烯基头孢菌素衍生物，以双环辛-2-烯或双环辛-3-烯形式存在，其中R1为保护基团或具有通式##STR2##的基团，其中R5为氢、烷基、乙烯基或氰甲基，或为保护基团，R6为氢或保护基团，R2为保护基团或酶可去除的基团，或R1为可带有各种取代基的酰基基团，R2表示保护基团，R3和R4相同或不同，表示烷基（可被羟基、烷氧基、氨基、烷基氨基或二烷基氨基取代）或苯基，或与氮原子一起形成含有另一个杂原子的饱和5元或6元杂环环，它们的E型和Z型及其混合物，可作为制备作为抗菌剂有用的3-硫代乙烯基头孢菌素的中介体。
• Fused heterocyclic derivatives, their production and use
  申请人：——

  公开号：US20030158245A1

  公开（公告）日：2003-08-21

  There is disclosed novel fused thiophene derivatives as prophylactic and therapeutic drugs for bone or articular diseases, industrially advantageous processes for production thereof, and novel production intermediates. Said fused thiophene derivatives are represented by the general formula (I): 1 wherein R 1 is an optionally substituted hydrocarbon, heterocyclic, sulfinyl, sulfonyl, hydroxyl, thiol or amino group,; R 2 is cyano, formyl, thioformyl, etc.; ring A is any of 2 (wherein R 3 is hydrogen or an optionally substituted hydrocarbon, heterocyclic, hydroxyl, amino, sulfonyl or acyl; R 14 is hydrogen, halogen, optionally subsituted hydrocarbon group, optionally subsituted heterocyclic group etc.; and ring B represents an optionally substituted 5- to 7-membered hydrocarbon ring.

  披露了一种新型的融合噻吩衍生物，作为用于骨骼或关节疾病的预防和治疗药物，以及用于其生产的工业优势工艺和新型生产中间体。所述融合噻吩衍生物由通式(I)表示：其中R1是可选择地取代的碳氢化合物、杂环、砜基、磺酰基、羟基、硫醇或氨基；R2是氰基、甲酰基、硫代甲酰基等；环A是其中R3是氢或可选择地取代的碳氢化合物、杂环、羟基、氨基、磺酰基或酰基；R14是氢、卤素、可选择地取代的碳氢基团、可选择地取代的杂环基团等；环B代表可选择地取代的5至7成员碳氢环。
• Process for producing phospholipid-containing drug
  申请人：——

  公开号：US20030185878A1

  公开（公告）日：2003-10-02

  The present invention provides a pharmaceutical preparation which is safe, little irritate subjects and comprises a water-insoluble or hardly water-soluble drug at a high level, and a simple and convenient process for producing the preparation. A process for producing a pharmaceutical composition comprising a water-insoluble or hardly water-soluble drug coated with phospholipid, said process comprising mixing a solution containing the water-insoluble or hardly water-soluble drug and phospholipid in an organic solvent with an aqueous solvent, emulsifying the resultant mixture and removing the organic solvent from the emulsion thus obtained to form a phospholipid coating film on the surface of the water-insoluble or hardly water-soluble drug.

  本发明提供了一种制药制剂，该制剂安全、对受试者刺激小，并且包含高水平的难溶于水或几乎不溶于水的药物，以及一种简单方便的制备过程。一种制备含有磷脂质包被的难溶于水或几乎不溶于水的药物的制药组合物的方法，该方法包括将含有难溶于水或几乎不溶于水的药物和磷脂质的溶液与有机溶剂混合后与水溶液乳化，然后从所得乳液中去除有机溶剂，以在难溶于水或几乎不溶于水的药物表面形成磷脂质包被膜。
• 2-(Arylimino-methyl)-3-(di-substituierte-amino)-alcylnitrile, Verfahren zu ihrer Herstellung und ihre Verwendung
  申请人：BAYER AG

  公开号：EP0704429A1

  公开（公告）日：1996-04-03

  2-(Arylimino-methyl)-3- (di-substituierte-amino) acrylnitrile lassen sich durch Umsetzung von β-Anilino-acrylnitrilen mit ortho-Formamiden gewinnen. Sie sind neue Verbindungen, und eignen sich als Ausgangsprodukte zur Herstellung von 4-Amino-5-iminiummethylen-2-pyrimidinen oder 4-Amino-5-formyl-2-pyrimidinen.

  2-(芳基亚氨基甲基)-3-(二取代氨基)丙烯腈可通过 β-苯胺基丙烯腈与原甲酰胺反应而获得。它们是新化合物，适合作为制备 4-氨基-5-亚氨甲基-2-嘧啶或 4-氨基-5-甲酰基-2-嘧啶的起始产物。
• PROCESS FOR PRODUCING PHOSPHOLIPID-CONTAINING DRUGS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1293197A1

  公开（公告）日：2003-03-19

  The present invention provides a pharmaceutical preparation which is safe, little irritate subjects and comprises a water-insoluble or hardly water-soluble drug at a high level, and a simple and convenient process for producing the preparation. A process for producing a pharmaceutical composition comprising a water-insoluble or hardly water-soluble drug coated with phospholipid, said process comprising mixing a solution containing the water-insoluble or hardly water-soluble drug and phospholipid in an organic solvent with an aqueous solvent, emulsifying the resultant mixture and removing the organic solvent from the emulsion thus obtained to form a phospholipid coating film on the surface of the water-insoluble or hardly water-soluble drug.

  本发明提供了一种安全、对受试者刺激小、含有高浓度水不溶性或难溶性药物的药物制剂，以及一种简单方便的制剂生产工艺。一种药物组合物的生产工艺，该药物组合物包括涂有磷脂的水不溶性或难溶性药物，所述工艺包括将有机溶剂中含有水不溶性或难溶性药物和磷脂的溶液与水溶剂混合，乳化所得混合物，并从所得乳液中除去有机溶剂，从而在水不溶性或难溶性药物表面形成磷脂涂膜。