3-hydroxy-2,4-dinitro-benzoic acid | 116779-73-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-hydroxy-2,4-dinitro-benzoic acid
• 英文别名: 3-Hydroxy-2,4-dinitro-benzoesaeure；3-Hydroxy-2,4-dinitrobenzoic acid
• CAS: 116779-73-8
• 化学式: C₇H₄N₂O₇
• 分子量: 228.118
• InChiKey: NOYULBGOASQKGQ-UHFFFAOYSA-N

物化性质

• 熔点：
  204 °C
• 沸点：
  372.0±42.0 °C(Predicted)
• 密度：
  1.838±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  149
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-hydroxy-2,4-dinitro-benzoic acid 在 溴 作用下， 生成 6-bromo-3-hydroxy-2,4-dinitro-benzoic acid
  参考文献：
  名称：

  Schmitt, Memorial des Poudres, 1937, vol. 27, p. 131,150

  摘要：

  DOI：
• 作为产物：
  描述：

  1-甲基-2,3,4-三硝基苯 在 chromium(VI) oxide 、 硫酸 、 sodium acetate 作用下， 生成 3-hydroxy-2,4-dinitro-benzoic acid
  参考文献：
  名称：

  Schmitt, Memorial des Poudres, 1937, vol. 27, p. 131,150

  摘要：

  DOI：

文献信息

• Schaefer, Memorial des Poudres, 1937, vol. 27, p. 153
  作者：Schaefer

  DOI：——

  日期：——
• Desflurane reduces the effective therapeutic infusion rate (ETI) of cisatracurium more than isoflurane, sevoflurane, or propofol
  作者：Thomas M. Hemmerling、Juergen Schuettler、Helmut Schwilden

  DOI：10.1007/bf03016828

  日期：2001.6

  Purpose: The present study investigated the interaction between the cumulative dose requirements of cisatracurium and anesthesia with isoflurane, sevoflurane, desflurane or propofol using closed-loop feedback control.Methods: Fifty-six patients (18-85 yr, vitrectomies of more than one hour) were studied. In the volatile anesthetics groups, anesthesia was maintained by 1.3 MAC of isoflurane, sevoflurane or desflurane; in the propofol group, anesthesia was maintained by a continuous infusion of 6-8 mg(.)kg(-1) hr(-1) propofol. After bolus application of 0.1 mg(.)kg(-1) cisatracurium, a T1%-level of 10% of control level (train-of-four stimulation every 20 sec) was maintained using closed-loop feedback controlled infusion of cisatracurium. The effective therapeutic infusion rate (ETI) was estimated from the asymptotic steady-state infusion rate I-ss. The I-SS was derived from fitting an asymptotic line to the measured cumulative dose requirement curve. The ETI of the different groups was compared using Kruskal-Wallis- test, followed by rank sum test, corrected for the number of comparisons, P <0.05 was regarded as showing significant difference.Results: ETI in the isoflurane group was 35.6 +/- 8.6 mug(.)m(-2) min(-1), in the sevoflurane group 36.4-+/- 11.9 mug m(-2) min(-1), in the desflurane group 23.8 +/- 6.3 mug(.)m(-2) min(-1). The ETI of the volatile anesthetic groups were all significantly lower than the ETI in the propofol group at 61.7 +/- 25.3 mug(.)m(-2)min(-1) (P <0.002). The ETI in the desflurane group was significantly lower than in all other groups (P <0.02).Conclusion: In comparison to propofol, isoflurane, sevoflurane and desflurane reduce the cumulative dose requirements of cisatracurium to maintain a 90% neuromuscular blockade by 42%, 41% and 60%, respectively.
• CLXV.—The nitro- and amino-derivatives of m-hydroxybenzoic acid
  作者：Victor Froelicher、Julius Berend Cohen

  DOI：10.1039/ct9211901425

  日期：——
• Beyer, Recueil des Travaux Chimiques des Pays-Bas, 1921, vol. 40, p. 623
  作者：Beyer

  DOI：——

  日期：——
• Schaefer, Chemisches Zentralblatt, 1939, vol. 110, # I, p. 2535
  作者：Schaefer

  DOI：——

  日期：——