2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol | 1371636-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol
• 英文别名: 2-(Benzenesulfonyl)-4-piperazin-1-ylphenol；2-(benzenesulfonyl)-4-piperazin-1-ylphenol
• CAS: 1371636-40-6
• 化学式: C₁₆H₁₈N₂O₃S
• 分子量: 318.397
• InChiKey: PZLAXBLYKDKNCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  78
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-对羟基苯基哌嗪 、 sodium benzenesulfonate 在 高氯酸 作用下， 以 乙醇 、 水 为溶剂， 以77%的产率得到2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol
  参考文献：
  名称：

  芳基亚磺酸存在下 4-(哌嗪-1-基)苯酚的电化学氧化

  摘要：

  Electrochemical oxidation of 4-(piperazin-1-yl)phenol has been studied in the presence of aryl sulfinic acids as nucleophiles in ethanol/water mixture (10/90) using cyclic voltammetry and controlled-potential coulometry methods. The results indicate that the electrochemically generated p-quinone-imine participates in Michael type addition reaction with aryl sulfinic acids and via an EC mechanism converts to the new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives. The present work has led to the development of a facile and environmentally friendly electrochemical method for the synthesis of some new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives under green conditions. (C) 2012 The Electrochemical Society. [DOI: 10.1149/2.033204jes] All rights reserved.

  DOI：

  10.1149/2.033204jes

文献信息

• Electrochemical Oxidation of 4-(Piperazin-1-yl)phenol in the Presence of Aryl Sulfinic Acids
  作者：Davood Nematollahi、Sadegh Khazalpour、Amene Amani

  DOI：10.1149/2.033204jes

  日期：——

  Electrochemical oxidation of 4-(piperazin-1-yl)phenol has been studied in the presence of aryl sulfinic acids as nucleophiles in ethanol/water mixture (10/90) using cyclic voltammetry and controlled-potential coulometry methods. The results indicate that the electrochemically generated p-quinone-imine participates in Michael type addition reaction with aryl sulfinic acids and via an EC mechanism converts to the new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives. The present work has led to the development of a facile and environmentally friendly electrochemical method for the synthesis of some new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives under green conditions. (C) 2012 The Electrochemical Society. [DOI: 10.1149/2.033204jes] All rights reserved.