(1S,4S)-2,5-Diazabicyclo(2.2.2)octane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (1S,4S)-2,5-Diazabicyclo(2.2.2)octane
• 英文别名: (1S,4S)-2,5-diazabicyclo[2.2.2]octane
• 化学式: C₆H₁₂N₂
• 分子量: 112.17
• InChiKey: DJWDAKFSDBOQJK-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Dual Pharmacophores - PDE4-Muscarinic Antagonistics
  申请人：Callahan James Francis

  公开号：US20090197871A1

  公开（公告）日：2009-08-06

  The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of/and or prophylaxis of respiratory diseases, including antiinflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.

  本发明涉及式(I)的新化合物，药物组合物及其在治疗中的应用，例如作为磷酸二酯酶IV (PDE4)的抑制剂和毒蕈碱乙酰胆碱受体 (mAChRs)的拮抗剂，用于治疗和/或预防呼吸道疾病，包括抗炎症和/或过敏性疾病，如慢性阻塞性肺病 (COPD)、哮喘、鼻炎 (例如过敏性鼻炎)、特应性皮炎或银屑病。
• DIKETO-PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS
  申请人：Wang Tao

  公开号：US20070249579A1

  公开（公告）日：2007-10-25

  This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with diketo piperazine and piperadine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.

  本公开提供具有药物和生物影响特性的化合物，它们的药物组合物和使用方法。具体而言，该公开涉及具有独特抗病毒活性的二酮哌嗪和哌啶衍生物。更具体地说，本公开涉及用于治疗艾滋病毒和艾滋病的化合物。
• [EN] SHP2 INHIBITORS<br/>[FR] INHIBITEURS DE SHP2
  申请人：IRBM S P A

  公开号：WO2021028362A1

  公开（公告）日：2021-02-18

  The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I).

  本发明涉及一种能够抑制SHP2磷酸酶活性的新化合物，其具有一般式(I)。
• SHP2 INHIBITORS
  申请人：C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening

  公开号：EP3772513A1

  公开（公告）日：2021-02-10

  The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I) indicated below:

  本发明涉及能够抑制 SHP2 磷酸酶活性的新化合物，其通式（I）如下所示：
• PYRIDOPYRIMIDINONES AND THEIR USE AS NMDA RECEPTOR MODULATORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3283487B1

  公开（公告）日：2019-10-16