2,3-Dihydro-1H-benz[e]inden-3-one oxime | 30696-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,3-Dihydro-1H-benz[e]inden-3-one oxime
• 英文别名: (NE)-N-(1,2-dihydrocyclopenta[a]naphthalen-3-ylidene)hydroxylamine
• CAS: 30696-25-4
• 化学式: C₁₃H₁₁NO
• 分子量: 197.236
• InChiKey: KFJADDAPVIBYDU-BUHFOSPRSA-N

物化性质

• 熔点：
  79 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
• 沸点：
  407.9±15.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-Dihydro-1H-benz[e]inden-3-one oxime 以 N-甲基乙酰胺 为溶剂， 生成 3-[3-(N-Phthalimido)-propoxyimino]-2,3-dihydro-1H-benz[e]indene
  参考文献：
  名称：

  Benz[e]indene derivatives

  摘要：

  该发明涉及新型的具有药用活性的苯并[e]茚衍生物，其制备方法，包含这些衍生物的药物组合物，以及所述苯并[e]茚衍生物在治疗某些疾病和制备适用于治疗这些疾病的药物组合物中的应用。根据该发明的新苯并[e]茚衍生物对应于以下通式##STR1## 其中A代表通式alk-NR.sup.1 R.sup.2的基团，其中alk代表一个C.sub.2-7烷基烃基，可选地携带一个羟基取代基，R.sup.1和R.sup.2分别独立地表示氢、C.sub.1-7烷基、C.sub.2-7烯基、C.sub.2-7炔基、单(C.sub.1-7)烷基氨基(C.sub.1-7)烷基、二(C.sub.1-7)烷基氨基(C.sub.1-7)烷基或C.sub.3-7环烷基；或者R.sup.1和R.sup.2与它们连接的氮原子一起形成一个4到7成员环，可选地包含一个氧原子或另一个氮原子，后者可能携带一个苯基、苄基、吡啶基、嘧啶基或C.sub.1-3烷基取代基，这些取代基反过来可能携带一个羟基或甲氧基或卤原子或卤苯基；或者R.sup.1和R.sup.2与它们连接的氮原子一起形成邻苯二甲酰亚胺基团；或者A代表嘧啶基、2,3-环氧丙基或通式--C(O)NHR.sup.3的基团，其中R.sup.3代表C.sub.1-7烷基、C.sub.2-7烯基或C.sub.3-8环烷基；R代表氢或C.sub.1-7烷基，立体异构体和光学活性异构体及其可能的混合物，以及这些化合物的进一步酸盐和季铵衍生物。

  公开号：

  US05439940A1

文献信息

• Benz[e]indene derivatives and a process for preparing them as well as medicaments containing them and the use of them
  申请人：EGIS GYOGYSZERGYAR RT.

  公开号：EP0595364B1

  公开（公告）日：1996-07-24
• OXIME COMPOUND, PHOTOSENSITIVE COMPOSITION, COLOR FILTER, PRODUCTION METHOD FOR THE COLOR FILTER, AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：Fujita Akinori

  公开号：US20110123929A1

  公开（公告）日：2011-05-26

  Provided are an oxime compound represented by General Formula (1), a photosensitive composition containing the oxime compound as a photopolymerization initiator, a production method for a color filter using the photosensitive composition, and a color filter obtained by the production method: in General Formula (1), R 1 represents a hydrogen atom, an acyl group, an alkoxycarbonyl group or an aryloxylcarbonyl group, each of which may have a substituent; R 2 represents or R 2 s each represent a halogen atom, an alkyl group, an aryl group, an alkyloxy group, an aryloxy group, an alkylthio group, an arylthio group or an amino group; m is an integer of 0 to 4; when m is an integer of 2 or more, R 2 s may be linked together to form a ring; and A represents a 4-, 5-, 6- or 7-membered ring.
• US5439940A
  申请人：——

  公开号：US5439940A

  公开（公告）日：1995-08-08
• Benz[e]indene derivatives
  申请人：EGIS Gyogyszergyar Rt.

  公开号：US05439940A1

  公开（公告）日：1995-08-08

  The invention relates to novel, pharmaceutically active benz[e]indene derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, further to the use of the said benz[e]indene derivatives in the treatment of certain diseases and in the preparation of pharmaceutical compositions suitable for the treatment of said diseases. The new benz[e]indene derivatives according to the invention correspond to the general formula ##STR1## wherein A represents a group of the formula alk-NR.sup.1 R.sup.2, wherein alk represents a C.sub.2-7 alkylene group optionally carrying a hydroxy substituent, R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, mono(C.sub.1-7)alkylamino(C.sub.1-7)alkyl, di(C.sub.1-7)alkylamino(C.sub.1-7)alkyl or C.sub.3-7 cycloalkyl; or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a 4 to 7 membered ring, optionally comprising an oxygen atom or a further nitrogen atom, which latter may carry a phenyl, benzyl, pyridyl, pyrimidinyl or C.sub.1-3 alkyl substituent which substituents may, in turn, bear a hydroxy or methoxy group or a halogen atom or a halophenyl group; or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a phthalimido group; or A represents pyrimidino, 2,3-epoxypropyl or a group of the formula --C(O)NHR.sup.3, wherein R.sup.3 stands for C.sub.1-7 alkyl, C.sub.2-7 alkenyl or C.sub.3-8 cycloalkyl; and R denotes hydrogen or C.sub.1-7 alkyl, stereoisomers and optically active isomers and the possible mixtures thereof, further acid addition salts and quaternary ammonium derivatives of these compounds.

  该发明涉及新型的具有药用活性的苯并[e]茚衍生物，其制备方法，包含这些衍生物的药物组合物，以及所述苯并[e]茚衍生物在治疗某些疾病和制备适用于治疗这些疾病的药物组合物中的应用。根据该发明的新苯并[e]茚衍生物对应于以下通式##STR1## 其中A代表通式alk-NR.sup.1 R.sup.2的基团，其中alk代表一个C.sub.2-7烷基烃基，可选地携带一个羟基取代基，R.sup.1和R.sup.2分别独立地表示氢、C.sub.1-7烷基、C.sub.2-7烯基、C.sub.2-7炔基、单(C.sub.1-7)烷基氨基(C.sub.1-7)烷基、二(C.sub.1-7)烷基氨基(C.sub.1-7)烷基或C.sub.3-7环烷基；或者R.sup.1和R.sup.2与它们连接的氮原子一起形成一个4到7成员环，可选地包含一个氧原子或另一个氮原子，后者可能携带一个苯基、苄基、吡啶基、嘧啶基或C.sub.1-3烷基取代基，这些取代基反过来可能携带一个羟基或甲氧基或卤原子或卤苯基；或者R.sup.1和R.sup.2与它们连接的氮原子一起形成邻苯二甲酰亚胺基团；或者A代表嘧啶基、2,3-环氧丙基或通式--C(O)NHR.sup.3的基团，其中R.sup.3代表C.sub.1-7烷基、C.sub.2-7烯基或C.sub.3-8环烷基；R代表氢或C.sub.1-7烷基，立体异构体和光学活性异构体及其可能的混合物，以及这些化合物的进一步酸盐和季铵衍生物。