2-methyl-3-(2-benzofuryl)-7-hydroxychromone | 36754-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-methyl-3-(2-benzofuryl)-7-hydroxychromone
• 英文别名: 3-benzofuran-2-yl-7-hydroxy-2-methyl-chromen-4-one；3-(1-Benzofuran-2-yl)-7-hydroxy-2-methylchromen-4-one
• CAS: 36754-48-0
• 化学式: C₁₈H₁₂O₄
• 分子量: 292.291
• InChiKey: JSYXCXQHRGGSNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methyl-3-(2-benzofuryl)-7-hydroxychromone 在 吡啶 、 盐酸羟胺 作用下， 以95%的产率得到3-methyl-4-(2-benzofuryl)-5-(2,4-dihydroxyphenyl)isoxazole
  参考文献：
  名称：

  异黄酮异类似物的化学。8.异黄酮的苯并呋喃类似物及其4-巯基衍生物与羟胺和肼的反应

  摘要：

  DOI：

  10.1007/bf00557736

文献信息

• Khilya,V.P. et al., Journal of Organic Chemistry USSR (English Translation), 1972, vol. 8, p. 1096 - 1101
  作者：Khilya,V.P. et al.

  DOI：——

  日期：——
• Chemistry of heteroanalogs of isoflavones
  作者：V. T. Khilya、L. G. Grishko、F. S. Babichev

  DOI：10.1007/bf00470216

  日期：1976.11
• PHYTOESTROGENIC FORMULATIONS FOR ALLEVIATION OR PREVENTION OF MENOPAUSAL SYMPTOMS
  申请人：Brinton Roberta Diaz

  公开号：US20100113586A1

  公开（公告）日：2010-05-06

  Select phytoestrogen pharmaceutical compositions and methods of use for preventing or reducing one or more symptoms associated with pre menopause, menopause, and/or post menopause are described herein. These select phytoestrogen formulations are composed only of two or more plant-derived estrogenic molecules and/or their structural analogues and exhibit binding preference to ERβ over ERα and agonist activity in the brain. These ERβ-selective phytoestrogen formulations cross the blood-brain-barrier and promote estrogen-associated neurotrophism and neuroprotection mechanisms in the brain, without activating proliferative mechanisms in the reproductive tissues and are therefore devoid of other estrogen-associated problematic aspects. The formulations can be administered enterally, transdermally, transmucosally, intranasally or parenterally. The formulations preferably contain combinations of compounds, and can be formulated for daily, sustained, delayed or weekly/monthly administration. In a preferred embodiment, these are administered to women who are in menopause or post menopausal, most preferably early in menopausal.
• PHYTOESTROGENIC FORMULATIONS FOR ALLEVIATION OR PREVENTION OF HAIR LOSS
  申请人：Brinton Roberta Diaz

  公开号：US20110091435A1

  公开（公告）日：2011-04-21

  Select phytoestrogen pharmaceutical compositions and methods of use for preventing or reducing one or more symptoms associated with hair loss or prostate cancer/prostate hypertrophy are described herein. These select phytoestrogen formulations are preferably composed only of two or more plant-derived estrogenic molecules and/or their structural analogues and exhibit binding preference to ERβ over ERα and agonist activity in non-reproductive tissues including brain.
• Chemistry of heteroanalogs of isoflavones. 8. Reaction of benzofuran analogs of isoflavones and their 4-thioxo derivatives with hydroxylamine and hydrazine
  作者：V. P. Khilya、L. G. Grishko、T. L. Davidkova

  DOI：10.1007/bf00557736

  日期：1980.7