6-Hept-1-ynylselanylhexan-1-ol | 1031433-81-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 6-Hept-1-ynylselanylhexan-1-ol
• 英文别名: 6-hept-1-ynylselanylhexan-1-ol
• CAS: 1031433-81-4
• 化学式: C₁₃H₂₄OSe
• 分子量: 275.293
• InChiKey: MUHMXRKSCLAUQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-溴正己醇 、 1-庚炔 在 正丁基锂 、 selenium 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 12.5h， 以94%的产率得到6-Hept-1-ynylselanylhexan-1-ol
  参考文献：
  名称：

  Synthesis of ω-hydroxy-α-alkyl/aryl-γ-organo-selenium and γ-organo-tellurium: a new class of organochalcogen compounds with antinociceptive activity

  摘要：

  We present here the results on the synthesis of alkynylselenoalcohols and alkynyltelluroalcohols using the reaction of lithium-alkynylchalcogenolates, generated via the reaction of alkynyllithium with elemental Se or Te, with bromo-alcohols. The reaction proceeded cleanly under mild reaction conditions, and alkynylchalcogenoalcohols were formed in good to excellent yields. The obtained compounds 2o and 2v were screened for antinociceptive activity using the acetic acid-induced writhing reaction in mice. Compound 2o administered by oral route at 5-50 mg/kg produced a significant inhibition of the acetic acid-induced abdominal constriction in mice. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.088

文献信息

• Synthesis of ω-hydroxy-α-alkyl/aryl-γ-organo-selenium and γ-organo-tellurium: a new class of organochalcogen compounds with antinociceptive activity
  作者：Afamefuna E. Okoronkwo、Alisson R. Rosário、Diego Alves、Lucielli Savegnago、Cristina W. Nogueira、Gilson Zeni

  DOI：10.1016/j.tetlet.2008.03.088

  日期：2008.5

  We present here the results on the synthesis of alkynylselenoalcohols and alkynyltelluroalcohols using the reaction of lithium-alkynylchalcogenolates, generated via the reaction of alkynyllithium with elemental Se or Te, with bromo-alcohols. The reaction proceeded cleanly under mild reaction conditions, and alkynylchalcogenoalcohols were formed in good to excellent yields. The obtained compounds 2o and 2v were screened for antinociceptive activity using the acetic acid-induced writhing reaction in mice. Compound 2o administered by oral route at 5-50 mg/kg produced a significant inhibition of the acetic acid-induced abdominal constriction in mice. (c) 2008 Elsevier Ltd. All rights reserved.