1-naphthyloxydichlorophosphine | 6951-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-naphthyloxydichlorophosphine
• 英文别名: α-naphthoxydichlorophosphine；Dichlor-(1-naphthyl)-phosphit；Phosphorigsaeure-dichlorid-<1>naphthylester；Phosphorigesaeure-naphthyl-(1)-ester-dichlorid；phosphorodichloridous acid naphthalen-1-yl ester；Phosphorigsaeure-(naphthyl-(1)-ester)-dichlorid；Dichlorophosphorigsaeure-(naphthyl-(1)-ester)；dichloro-[1]naphthyloxy-phosphine；Dichlor-[1]naphthyloxy-phosphin；Phosphorigsaeure-α-naphthylester-dichlorid；(Naphthyl-(1))-dichlorophosphit；1-Naphthyl phosphorodichloridite；dichloro(naphthalen-1-yloxy)phosphane
• CAS: 6951-02-6
• 化学式: C₁₀H₇Cl₂OP
• 分子量: 245.045
• InChiKey: BSEZFPVGYWDGNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-naphthyloxydichlorophosphine 以 正己烷 为溶剂， 生成 Dinaphthalen-1-yloxy(piperidin-1-yl)phosphane
  参考文献：
  名称：

  Dismutation of Diamidoarylphosphites

  摘要：

  Some examples of spontaneous dismutation of diamidoarylphosphites in different solvents were studied, and features of the process were revealed.

  DOI：

  10.1080/714040960
• 作为产物：
  描述：

  萘酚 在 三氯化磷 作用下， 生成 1-naphthyloxydichlorophosphine
  参考文献：
  名称：

  Kunz, Chemische Berichte, 1894, vol. 27, p. 2563

  摘要：

  DOI：

文献信息

• Enantioselective Rhodium-Catalyzed Addition of Arylboronic Acids to Aldehydes Using Chiral Spiro Monophosphite Ligands
  作者：Hai-Feng Duan、Jian-Hua Xie、Wen-Jian Shi、Qi Zhang、Qi-Lin Zhou

  DOI：10.1021/ol060360c

  日期：2006.3.1

  [reaction: see text] Highly efficient rhodium-catalyzed asymmetric addition of arylboronic acids to aldehydes has been realized by using chiral spiro monophosphite ligands, affording diarylmethanols in excellent yields and good enantiomeric excesses.

  [反应：见正文]通过使用手性螺一亚磷酸酯配体实现了铑催化芳基硼酸向醛的高效不对称加成，从而以优异的收率和良好的对映体过量提供了二芳基甲醇。
• Process for transhalogenating a halophosphorus compound with fluoride
  申请人：ETHYL CORPORATION

  公开号：EP0312790A2

  公开（公告）日：1989-04-26

  Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are trans­halogenated with fluorine by reaction with a fluoride salt, e.g., KF or ammonium fluoride, in the presence of a hydrogen halide salt of a pyridine-type nitrogen base, e.g., pyridine hydrochloride.

  在吡啶型氮基（如盐酸吡啶）的卤化氢盐存在下，与氟化盐（如 KF 或氟化铵）反应，使至少有一个氯、溴或碘直接与磷键合的磷化合物与氟反卤化。
• Process for transhalogenating a halophosphorus compound with hydrogen fluoride
  申请人：ALBEMARLE CORPORATION

  公开号：EP0357048A2

  公开（公告）日：1990-03-07

  Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are trans­halogenated with fluorine by reaction with anhydrous hydrogen fluoride in an inert solvent in a manner such that said anhydrous hydrogen fluoride is added to said phosphorus compound at a rate such that said anhydrous hydrogen fluoride reacts with said phosphorus compound without the accumulation of an amount of unreacted anhy­drous hydrogen fluoride which is sufficient to cause substantial decomposition of the desired fluorophosphorus product.

  至少有一个氯、溴或碘直接与磷键合的磷化合物，通过在惰性溶剂中与无水氟化氢反应，用氟进行反卤化，反应的方式是将所述无水氟化氢加入到所述磷化合物中，加入的速度使所述无水氟化氢与所述磷化合物反应，而不会积累一定量的未反应的无水氟化氢，足以导致所需的氟磷产品的大量分解。
• PHOSPHORAMIDATE DERIVATIVES OF 5-FLUORO-2'-DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER
  申请人：Nucana PLC

  公开号：EP4023299A1

  公开（公告）日：2022-07-06

  Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.

  5-氟-2'-脱氧尿苷的磷酰胺衍生物被公开用于治疗癌症，特别是用于治疗患者出现抗药性的癌症，例如，患者细胞中核苷转运蛋白水平降低和/或核苷激酶缺陷细胞和/或支原体感染细胞和/或胸苷酸合成酶水平升高的细胞。
• Dzhundubaev,K.D. et al., Journal of general chemistry of the USSR, 1972, vol. 42, p. 327 - 329
  作者：Dzhundubaev,K.D. et al.

  DOI：——

  日期：——