2,5-dimethyl-N-(3-phenylpropyl)furan-3-carboxamide | 727387-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2,5-dimethyl-N-(3-phenylpropyl)furan-3-carboxamide
• CAS: 727387-38-4
• 化学式: C₁₆H₁₉NO₂
• mdl: MFCD06192063
• 分子量: 257.332
• InChiKey: RBHSGHNFZBWAKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,5-二甲基-3-呋喃酸 、 3-苯基-1-丙胺 在 三甲基铝 作用下， 以 甲苯 为溶剂， 反应 24.5h， 以92%的产率得到2,5-dimethyl-N-(3-phenylpropyl)furan-3-carboxamide
  参考文献：
  名称：

  AlMe₃-Promoted Formation of Amides from Acids and Amines

  摘要：

  In the presence of AlMe3, amines can be directly coupled with acids through dimethylalumlnum amide Intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected secondary amino acids, and acids with poor solubility were coupled smoothly to give the desired products in 55-98% yields.

  DOI：

  10.1021/ol203007s

文献信息

• AlMe₃-Promoted Formation of Amides from Acids and Amines
  作者：Jianqing Li、Krishnananthan Subramaniam、Daniel Smith、Jennifer X. Qiao、Jie Jack Li、Jingfang Qian-Cutrone、John F. Kadow、Gregory D. Vite、Bang-Chi Chen

  DOI：10.1021/ol203007s

  日期：2012.1.6

  In the presence of AlMe3, amines can be directly coupled with acids through dimethylalumlnum amide Intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected secondary amino acids, and acids with poor solubility were coupled smoothly to give the desired products in 55-98% yields.