I+/--(Chloromethyl)benzenepropanoic acid | 1373219-06-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: I+/--(Chloromethyl)benzenepropanoic acid
• 英文别名: 2-benzyl-3-chloropropanoic acid
• CAS: 1373219-06-7
• 化学式: C₁₀H₁₁ClO₂
• 分子量: 198.64
• InChiKey: TWXBPDQSTAGDFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PROCESS FOR PRODUCING 2-ARALKYLPROPIONIC ACID DERIVATIVE
  申请人：KANEKA CORPORATION

  公开号：EP1466895A1

  公开（公告）日：2004-10-13

  A process for easily and industrially advantageously producing a high-purity 2-aralkyl-3-acetylthiopropionic acid and a high-purity 2-aralkylpropionic acid having a leaving group in the 3-position from easily available compounds. A 2-aralkyl-1-propanol having a sulfonyloxy group or halogen atom in the 3-position is oxidized with a permanganate under acidic conditions to produce a high-purity 2-aralkylporpionic acid having sulfonyloxy or the halogen in the 3-position. This acid is reacted with a thioacetate in the presence of water to produce a high-purity 2-aralkyl-3-acetylthiopropionic acid.

  一种易于工业优势生产高纯度2-芳基-3-乙酰基硫代丙酸和高纯度2-芳基丙酸的方法，该方法使用易得化合物。将在3位位置具有磺酰氧基团或卤素原子的2-芳基-1-丙醇在酸性条件下氧化为高纯度的具有磺酰氧基团或卤素在3位位置的2-芳基丙酸。该酸与硫代乙酸在水的存在下反应，生成高纯度的2-芳基-3-乙酰基硫代丙酸。
• Process for producing 2-aralkylpropionic acid derivative
  申请人：Fuse Yoshihide

  公开号：US20050143593A1

  公开（公告）日：2005-06-30

  A process for easily and industrially advantageously producing a high-purity 2-aralkyl-3-acetylthiopropionic acid and a high-purity 2-aralkylpropionic acid having a leaving group in the 3-position from easily available compounds. A 2-aralkyl-1-propanol having a sulfonyloxy group or halogen atom in the 3-position is oxidized with a permanganate under acidic conditions to produce a high-purity 2-aralkylporpionic acid having sulfonyloxy or the halogen in the 3-position. This acid is reacted with a thioacetate in the presence of water to produce a high-purity 2-aralkyl-3-acetylthiopropionic acid.

  一种利用容易获得的化合物生产高纯度 2-烷基-3-乙酰基硫代丙酸和 3-位有离去基团的高纯度 2-烷基丙酸的工艺。在酸性条件下，用高锰酸盐氧化在 3 位上具有磺酰氧基或卤素原子的 2-烷基-1-丙醇，生成在 3 位上具有磺酰氧基或卤素的高纯度 2-烷基硼酸。这种酸在有水的情况下与硫代乙酸酯反应，生成高纯度的 2-烷基-3-乙酰基硫代丙酸。
• NOVEL COMPOUNDS, THEIR PREPARATION AND THEIR USES
  申请人：Inhibikase Therapeutics, Inc.

  公开号：EP2903979B1

  公开（公告）日：2020-08-19
• JPH07316094A
  申请人：——

  公开号：JPH07316094A

  公开（公告）日：1995-12-05
• US5587510A
  申请人：——

  公开号：US5587510A

  公开（公告）日：1996-12-24