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(S)-tert-butyl 4-(1-fluoro-2-hydroxyethyl)piperidine-1-carboxylate | 1280608-32-3

中文名称
——
中文别名
——
英文名称
(S)-tert-butyl 4-(1-fluoro-2-hydroxyethyl)piperidine-1-carboxylate
英文别名
Tert-butyl (S)-4-(1-fluoro-2-hydroxyethyl)piperidine-1-carboxylate;tert-butyl 4-[(1S)-1-fluoro-2-hydroxyethyl]piperidine-1-carboxylate
(S)-tert-butyl 4-(1-fluoro-2-hydroxyethyl)piperidine-1-carboxylate化学式
CAS
1280608-32-3
化学式
C12H22FNO3
mdl
——
分子量
247.31
InChiKey
QGEYVOBSVRXLBI-SNVBAGLBSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    342.8±12.0 °C(Predicted)
  • 密度:
    1.107±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    1.6
  • 重原子数:
    17
  • 可旋转键数:
    4
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.92
  • 拓扑面积:
    49.8
  • 氢给体数:
    1
  • 氢受体数:
    4

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • [EN] N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE<br/>[FR] PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES N-SULFONYLÉS ET LEUR PROCÉDÉ D'UTILISATION
    申请人:ABBVIE S Á R L
    公开号:WO2017060874A1
    公开(公告)日:2017-04-13
    The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
    本发明提供了一种具有以下结构的化合物(I),其中R1、R2、R3、R4、R5和R6具有规范中定义的任何值,以及其药学上可接受的盐,这些化合物在治疗由CFTR介导和调节的疾病和症状中是有用的,包括囊性纤维化、Sjögren综合征、胰腺功能不全、慢性阻塞性肺病和慢性阻塞性气道疾病。还提供了由一个或多个具有结构(I)的化合物组成的药物组合物。
  • [EN] COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LA DÉGRADATION CIBLÉE DE L'IRAK-4
    申请人:ARVINAS OPERATIONS INC
    公开号:WO2022266258A1
    公开(公告)日:2022-12-22
    This application relates to a bifunctional compound having the structure of Formula (I): ITM-LNK-CLM (I), or a pharmaceutically acceptable salt, solvate, enantiomer, stereoisomer, or isotopic derivative thereof, which contains, on one end, a cereblon E3 ubiquitin ligase that binds to the E3 ubiquitin ligase and, on the other end, a moiety that binds the target protein, Interleukin-1 Receptor-Associated Kinase 4 (IRAK-4), such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from cellular signaling mediated by the target protein are treated or prevented with bifunctional compounds and compositions of the present disclosure.
    本申请涉及一种具有式(I)结构的双功能化合物:ITM-LNK-CLM(I),或其药学上可接受的盐、溶剂合物、对映体、立体异构体或同位素衍生物,其一端含有结合E3泛素连接酶的谷酰胺酰化酶(Cereblon E3 ubiquitin ligase),另一端含有结合目标蛋白Interleukin-1 Receptor-Associated Kinase 4 (IRAK-4)的基团,使目标蛋白靠近泛素连接酶以实现目标蛋白的降解和抑制。本公开的双功能化合物展示了与目标蛋白的降解/抑制相关的广泛药理活性。使用本公开的双功能化合物和组合物治疗或预防由目标蛋白介导的细胞信号传导引起的疾病或障碍。
  • N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use
    申请人:AbbVie S.à.r.l.
    公开号:US10259810B2
    公开(公告)日:2019-04-16
    The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
    本发明提供了式 (I) 的化合物 其中 R1、R2、R3、R4、R5 和 R6 具有说明书中定义的任一值,及其药学上可接受的盐,可作为治疗由 CFTR 介导和调节的疾病和病症的药物,包括囊性纤维化、Sjögren 综合征、胰腺功能不全、慢性阻塞性肺病和慢性阻塞性气道疾病。还提供了由一种或多种式(I)化合物组成的药物组合物。
  • N-sulfonylated-pyrazolo[3,4-b]pyridin-6-carboxamides and method of use
    申请人:AbbVie S.à.r.l.
    公开号:US10647717B2
    公开(公告)日:2020-05-12
    The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
    本发明提供了式 (I) 的化合物 其中 R1、R2、R3、R4、R5 和 R6 具有说明书中定义的任一值,及其药学上可接受的盐,可作为治疗由 CFTR 介导和调节的疾病和病症的药物,包括囊性纤维化、Sjögren 综合征、胰腺功能不全、慢性阻塞性肺病和慢性阻塞性气道疾病。还提供了由一种或多种式(I)化合物组成的药物组合物。
  • N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE
    申请人:AbbVie Overseas S.à r.l.
    公开号:EP3359541B1
    公开(公告)日:2020-08-05
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