3-Trimethylsilanylethynyl-oct-7-en-1-ol | 151654-94-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 3-Trimethylsilanylethynyl-oct-7-en-1-ol
• CAS: 151654-94-3
• 化学式: C₁₃H₂₄OSi
• 分子量: 224.418
• InChiKey: QHVOOAWVCUZBSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.22
• 重原子数：
  15.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  3-Trimethylsilanylethynyl-oct-7-en-1-ol 在 sodium hydroxide 、 偶氮二甲酸二异丙酯 、 四丁基氟化铵 、 双氧水 、 溶剂黄146 、 9-bromo-9-borabicyclo[3.3.1]nonane 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.5h， 生成 N-[3-(1-bromoethenyl)oct-7-enyl]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Synthesis of bicyclic nitrogen compounds via tandem intramolecular Heck cyclization and subsequent trapping of intermediate .pi.-allylpalladium complexes

  摘要：

  Intramolecular palladium-mediated three-component cyclizations of substrates containing vinyl halide, olefin, and sulfonamide moieties to generate a diverse group of nitrogen heterocycles have been developed. The methodology has been applied to construction of both fused and bridged bicyclic systems. The strategy can also be used for spirocyclizations. This chemistry involves regiospecific generation of pi-allylpalladium complexes via Heck reactions of vinyl halides and simple olefins, followed by nucleophilic addition of sulfonamide anions to these intermediates.

  DOI：

  10.1021/jo00072a030
• 作为产物：
  描述：

  (3-chloro-1-propynyl)trimethylsilane 在 正丁基锂 、 碘 、 magnesium 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 40.5h， 生成 3-Trimethylsilanylethynyl-oct-7-en-1-ol
  参考文献：
  名称：

  Synthesis of bicyclic nitrogen compounds via tandem intramolecular Heck cyclization and subsequent trapping of intermediate .pi.-allylpalladium complexes

  摘要：

  Intramolecular palladium-mediated three-component cyclizations of substrates containing vinyl halide, olefin, and sulfonamide moieties to generate a diverse group of nitrogen heterocycles have been developed. The methodology has been applied to construction of both fused and bridged bicyclic systems. The strategy can also be used for spirocyclizations. This chemistry involves regiospecific generation of pi-allylpalladium complexes via Heck reactions of vinyl halides and simple olefins, followed by nucleophilic addition of sulfonamide anions to these intermediates.

  DOI：

  10.1021/jo00072a030