tert-butyl (2R)-4-(3-methoxy-4-methoxycarbonylphenyl)-2-methylpiperazine-1-carboxylate | 1845753-87-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl (2R)-4-(3-methoxy-4-methoxycarbonylphenyl)-2-methylpiperazine-1-carboxylate
• 英文别名: Tert-butyl (R)-4-(3-methoxy-4-(methoxycarbonyl)phenyl)-2-methylpiperazine-1-carboxylate
• CAS: 1845753-87-8
• 化学式: C₁₉H₂₈N₂O₅
• 分子量: 364.442
• InChiKey: CIGKIMMVNKZGAV-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• N-(IMIDAZO[1,2-A]PYRAZIN-6-YL)-BENZAMIDE COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3160967B1

  公开（公告）日：2019-05-08
• COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：Hoffmann-La Roche Inc.

  公开号：US20170197969A1

  公开（公告）日：2017-07-13

  The present invention provides compounds of formula (I) wherein A, X 1 , X 2 , R 1 , R 2 , R 3 , R 4 and R 5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
• US9975900B2
  申请人：——

  公开号：US9975900B2

  公开（公告）日：2018-05-22