Methyl 4-(1-tritylimidazol-4-yl)butanoate | 199007-46-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Methyl 4-(1-tritylimidazol-4-yl)butanoate
• 英文别名: methyl 4-(1-tritylimidazol-4-yl)butanoate
• CAS: 199007-46-0
• 化学式: C₂₇H₂₆N₂O₂
• 分子量: 410.516
• InChiKey: DVYKUMNEWPJLSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 4-(1-tritylimidazol-4-yl)butanoate 在 盐酸 、 lithium diisopropyl amide 作用下， 以 1,4-二氧六环 为溶剂， 反应 8.0h， 生成 2-Benzyl-4-(1H-imidazol-4-yl)-butyric acid; hydrochloride
  参考文献：
  名称：

  A new type of carboxypeptidase a inhibitors designed using an imidazole as a zinc coordinating ligand

  摘要：

  2-(4-Imidazoyl)hydrocinnamic acid (1) and its congeners (2-4) having different length of alkyl chain spacers between the imidazole ring and the a-carbon to the carboxylate of 1 have been designed, synthesized and evaluated as inhibitors for carboxypeptidase A to show that they are competitive inhibitors for the enzyme. Inhibitor 1 was most potent having the K-i value of 0.8 mu M. The present study demonstrates that imidazole ring is an effective zinc coordinating ligand that can be useful for the design of inhibitors for zinc proteases. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00134-x
• 作为产物：
  描述：

  1-三苯甲基咪唑-4-甲醛 在 palladium on activated charcoal sodium hydroxide 、 硫酸 、 氢气 、 sodium hydride 、 potassium carbonate 、 二甲基亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 25.0h， 生成 Methyl 4-(1-tritylimidazol-4-yl)butanoate
  参考文献：
  名称：

  A new type of carboxypeptidase a inhibitors designed using an imidazole as a zinc coordinating ligand

  摘要：

  2-(4-Imidazoyl)hydrocinnamic acid (1) and its congeners (2-4) having different length of alkyl chain spacers between the imidazole ring and the a-carbon to the carboxylate of 1 have been designed, synthesized and evaluated as inhibitors for carboxypeptidase A to show that they are competitive inhibitors for the enzyme. Inhibitor 1 was most potent having the K-i value of 0.8 mu M. The present study demonstrates that imidazole ring is an effective zinc coordinating ligand that can be useful for the design of inhibitors for zinc proteases. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00134-x

文献信息

• 1,(3,)5-SUBSTITUTED IMIDAZOLES, THEIR USE IN THE TREATMENT OF HYPERTENSION AND METHODS FOR THEIR PREPARATION
  申请人：Matsoukas John

  公开号：US20100166837A1

  公开（公告）日：2010-07-01

  The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists suitable for transdermal delivery. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases.

  本发明提供了新颖的1,5和1,3,5-取代咪唑化合物，其以亲水或亲脂形式存在，可用作适合经皮途径给药的血管紧张素II ATI受体拮抗剂。该发明还提供了含有这些化合物的药物组合物，用于制备化合物的方法和中间体，以及它们在治疗高血压和心血管疾病的方法中的应用。