4-Cyano-2,5-dimethylthiophen | 31883-38-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 4-Cyano-2,5-dimethylthiophen
• 英文别名: 2.5-Dimethyl-3-cyanothiophen；2,5-dimethyl-thiophene-3-carbonitrile；2,5-Dimethyl-thiophen-3-carbonitril；2,5-Dimethylthiophene-3-carbonitrile
• CAS: 31883-38-2
• 化学式: C₇H₇NS
• 分子量: 137.205
• InChiKey: WVDRPXZCCUCIAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  52
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Cyano-2,5-dimethylthiophen 在 氢氧化钾 作用下， 生成 2,5-dimethyl-thiophene-3-carboxylic acid amide
  参考文献：
  名称：

  Justoni, Gazzetta Chimica Italiana, 1941, vol. 71, p. 375,384

  摘要：

  DOI：
• 作为产物：
  描述：

  2-acetyl-4-oxopentanenitrile 在 diphosphorus trisulfide 作用下， 生成 4-Cyano-2,5-dimethylthiophen
  参考文献：
  名称：

  Justoni, Gazzetta Chimica Italiana, 1941, vol. 71, p. 375,384

  摘要：

  DOI：

文献信息

• Ink and ink set for inkjet recording
  申请人：Fujifilm Corporation

  公开号：EP2455431A1

  公开（公告）日：2012-05-23

  To provide inks and ink sets for inkjet recording, which have good fastness and good jet-out stability and which give good images with no bleeding trouble, a magenta ink for inkjet printing contains a first dye; and a second dye having a different structure from the first dye, the first dye and the second dye each independently having an oxidation potential higher than 1.0 V versus SCE, wherein the first dye is an azo dye comprising an azo group, each end of the azo group having a hetero ring.

  为了提供用于喷墨记录的墨水和墨水套件，它们具有良好的牢度和良好的喷射稳定性，并且能够提供无渗色问题的良好图像，一种用于喷墨打印的品红色墨水包含第一染料；以及具有与第一染料不同结构的第二染料，第一染料和第二染料各自独立地具有相对于 SCE 高于 1.0 V 的氧化电位，其中第一染料是包含偶氮基团的偶氮染料，偶氮基团的每个末端都具有杂环。
• INK COMPOSITION, INKJET PRINTING INK, AND INKJET PRINTING METHOD
  申请人：FUJIFILM Corporation

  公开号：EP2687565A1

  公开（公告）日：2014-01-22

  Provided are an ink composition having a fastness at a high level and having an excellent grey balance in a range from a high-concentration region to a low-concentration region, an ink for inkjet recording using the ink composition, and an inkjet recording method using the ink for inkjet recording using the ink for inkjet recording. An ink composition containing at least two kinds of water-soluble long-wavelength dyes whose absorption spectrum in an aqueous solvent has a maximum wavelength of 550 nm to 700 nm, in which at least one kind of the water-soluble long-wavelength dyes is a first water-soluble long-wavelength dye of an azo compound represented by the following Formula (1), at least one kind of the water-soluble long-wavelength dyes is a second water-soluble long-wavelength dye that is different from the first water-soluble long-wavelength dye, and the second water-soluble long-wavelength dye is a compound having two to four azo groups conjugated with each other per molecule, an ink for inkjet recording using the ink composition, and an inkjet recording method using the ink for inkjet recording using the ink for inkjet recording. Formula (1): (In Formula (1), A represents a substituted or unsubstituted aryl group or a substituted or unsubstituted nitrogen-containing 5-membered heterocyclic group. G represents a nitrogen atom or -C(R2)=. R2 represents a hydrogen atom, a sulfo group, a carboxyl group, a substituted or unsubstituted carbamoyl group or a cyano group. Y2, Y3 and Y4 each independently represent a hydrogen atom or a monovalent substituent. Y2, Y3 and Y4 may be bound with each other to form a ring. All of Y2, Y3 and Y4 do not represent a hydrogen atom at the same time. M's each independently represent a hydrogen atom or a monovalent countercation.)

  本发明提供了一种在高浓度区域到低浓度区域范围内具有高牢度和优异灰平衡的墨水组合物，一种使用该墨水组合物的喷墨记录墨水，以及一种使用该墨水的喷墨记录方法。 一种墨水组合物，含有至少两种在水性溶剂中吸收光谱最大波长为 550 纳米至 700 纳米的水溶性长波长染料，其中至少一种水溶性长波长染料是由下式（1）表示的偶氮化合物的第一种水溶性长波长染料、至少一种水溶性长波长染料是不同于第一种水溶性长波长染料的第二种水溶性长波长染料，且第二种水溶性长波长染料是每个分子中具有 2 至 4 个相互共轭的偶氮基团的化合物，一种使用该墨水组合物的喷墨记录用墨水，以及一种使用该墨水组合物的喷墨记录用墨水的喷墨记录方法。 式（1）： 式（1）中，A 代表取代或未取代的芳基或取代或未取代的含氮 5 元杂环基团。R2 代表氢原子、磺基、羧基、取代或未取代的氨基甲酰基或氰基。Y2、Y3 和 Y4 各自独立地代表一个氢原子或一个一价取代基。Y2、Y3 和 Y4 可相互结合形成一个环。所有 Y2、Y3 和 Y4 不能同时代表一个氢原子。M 各独立地代表一个氢原子或一个一价取代基）。
• Human androgen receptor DNA-binding domain (DBD) compounds as therapeutics and methods for their use
  申请人：The University of British Columbia

  公开号：US10011573B2

  公开（公告）日：2018-07-03

  A compound having the structure of Formula I, wherein A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and E is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ovarian, endometrial or bladder cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, precocious puberty and age related macular degeneration. The use of the compounds for the manufacture of a medicament for modulating AR activity, a method of treatment using such compounds and a pharmaceutical composition and a commercial package comprising said compounds are also described.

  具有式 I 结构的化合物，其中 A 是取代或未取代的芳基或杂芳基，D 是取代或未取代的 5 或 6 元杂芳基或杂环基，E 是取代或未取代的芳基、杂芳基、环烷基或杂环基。这些化合物可用于治疗雄激素调节适应症，包括癌症（前列腺癌、乳腺癌、卵巢癌、子宫内膜癌或膀胱癌）、脱发、痤疮、多毛症、卵巢囊肿、多囊卵巢病、性早熟和老年性黄斑变性。此外，还描述了这些化合物在制造调节 AR 活性的药物中的用途、使用这些化合物的治疗方法以及包含上述化合物的药物组合物和商业包装。
• [EN] POLYCYCLIC COMPOUNDS FOR INHIBITING RNA HELICASE DHX33 AND USE THEREOF<br/>[FR] COMPOSÉS POLYCYCLIQUES POUR INHIBER L'ARN HÉLICASE DHX33 ET LEUR UTILISATION<br/>[ZH] 一类抑制RNA解旋酶DHX33的多环化合物及其应用
  申请人：[en]SHENZHEN KEYE LIFE TECHNOLOGIES, CO., LTD;[zh]深圳开悦生命科技有限公司

  公开号：WO2022127199A1

  公开（公告）日：2022-06-23

  本发明涉及一类抑制RNA解旋酶DHX33的多环化合物及其应用。特别地，本发明涉及式VII所示的化合物或其药学上可接受的形式、包含其的药物组合物、其制备方法、及其用于预防和/或治疗DHX33相关疾病的医药用途。
• AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
  申请人：Astra Pharmaceuticals Limited

  公开号：EP0892784A1

  公开（公告）日：1999-01-27