tert-butyl N-[2-methyl-1-(5-methylthiophen-2-yl)propyl]carbamate | 1373935-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: tert-butyl N-[2-methyl-1-(5-methylthiophen-2-yl)propyl]carbamate
• CAS: 1373935-65-9
• 化学式: C₁₄H₂₃NO₂S
• 分子量: 269.408
• InChiKey: IHJYDKHGVPSMAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基噻吩 、 氨基甲酸叔丁酯 、 异丁醛 在 碘 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以48%的产率得到tert-butyl N-[2-methyl-1-(5-methylthiophen-2-yl)propyl]carbamate
  参考文献：
  名称：

  Iodine-catalyzed, one-pot, three-component aza-Friedel–Crafts reaction of electron-rich arenes with aldehyde/carbamate combinations

  摘要：

  Iodine is shown to be an efficient catalyst for a one-step, three-component aza-Friedel-Crafts reaction of activated arenes or heteroarenes with benzyl or tert-butyl carbamates in combination with a wide variety of aldehydes in toluene under 'open-flask' and mild conditions. In the presence of 5 mol % of iodine in toluene at room temperature, the reaction gives the corresponding N-CBz or N-Boc protected a-branched amines, selectively, in good to excellent yields. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.03.024

文献信息

• Iodine-catalyzed, one-pot, three-component aza-Friedel–Crafts reaction of electron-rich arenes with aldehyde/carbamate combinations
  作者：Jaray Jaratjaroonphong、Suppachai Krajangsri、Vichai Reutrakul

  DOI：10.1016/j.tetlet.2012.03.024

  日期：2012.5

  Iodine is shown to be an efficient catalyst for a one-step, three-component aza-Friedel-Crafts reaction of activated arenes or heteroarenes with benzyl or tert-butyl carbamates in combination with a wide variety of aldehydes in toluene under 'open-flask' and mild conditions. In the presence of 5 mol % of iodine in toluene at room temperature, the reaction gives the corresponding N-CBz or N-Boc protected a-branched amines, selectively, in good to excellent yields. (C) 2012 Published by Elsevier Ltd.