(3-Chlorophenyl)-[4-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl]methanone | 1027339-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (3-Chlorophenyl)-[4-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl]methanone
• CAS: 1027339-27-0
• 化学式: C₁₇H₁₄ClN₅O₄S
• 分子量: 419.848
• InChiKey: CONKNLVBKVEKDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  137
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]piperazine 、 3-氯苯甲酰氯 在 吡啶 作用下， 以 苯 为溶剂， 以80%的产率得到(3-Chlorophenyl)-[4-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl]methanone
  参考文献：
  名称：

  Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines

  摘要：

  The synthesis and anti-leishmanial activity of nitroheteroaryl-1,3,4-thiadiazole- based compounds including 1-[5-(5-nitrofuran2- yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines were described. Most of the synthesized compounds exhibited potent anti-leishmanial activity against both promastigote and amastigote forms of Leishmania major at non-cytotoxic concentrations. In general, 5- nitrofuran derivatives were more active than the corresponding 5- nitrothiophene analogues. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.02.052

文献信息

• Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines
  作者：Mina Behrouzi-Fardmoghadam、Fatemeh Poorrajab、Sussan Kaboudanian Ardestani、Saeed Emami、Abbas Shafiee、Alireza Foroumadi

  DOI：10.1016/j.bmc.2008.02.052

  日期：2008.4

  The synthesis and anti-leishmanial activity of nitroheteroaryl-1,3,4-thiadiazole- based compounds including 1-[5-(5-nitrofuran2- yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines were described. Most of the synthesized compounds exhibited potent anti-leishmanial activity against both promastigote and amastigote forms of Leishmania major at non-cytotoxic concentrations. In general, 5- nitrofuran derivatives were more active than the corresponding 5- nitrothiophene analogues. (c) 2008 Elsevier Ltd. All rights reserved.