isopropyl-thiophosphoramidic acid diethyl ester | 6737-25-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 英文名称: isopropyl-thiophosphoramidic acid diethyl ester
• 英文别名: O,O-diethyl isopropylphosphoramidothioate；O,O-diethylisopropylphosphoramidothioate；N-diethoxyphosphinothioylpropan-2-amine
• CAS: 6737-25-3
• 化学式: C₇H₁₈NO₂PS
• 分子量: 211.265
• InChiKey: OMMLCZVZRDPYQH-UHFFFAOYSA-N

物化性质

• 沸点：
  232.5±23.0 °C(Predicted)
• 密度：
  1.066±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  isopropyl-thiophosphoramidic acid diethyl ester 在 sulphur dichloride 、 三乙胺 作用下， 以 正己烷 为溶剂， 生成 O,O-Diethyl N-(chlorothio)-N-isopropylphosphoramidothioate
  参考文献：
  名称：

  Process for preparing N-[(phosphinyl)amino]thio- and N-[(phosphinyl)amino]t

  摘要：

  已合成并测试了一些新的氨硫甲酸酯磷酸衍生物作为杀虫剂。这些新化合物对昆虫、螨和线虫具有活性。N-[(磷氨基)氨基]硫基和N-[(磷硫酰)氨基]硫基甲酸酯可通过将磷酸酰胺与二氯化硫反应的一般程序轻松制备，从而获得相应的N-(氯硫)磷酸酰胺，该反应物将与甲基氨基甲酸酯反应，从而产生本发明的相应化合物，即N-[(磷氨基)氨基]硫基和N-[(磷硫酰)氨基]硫基甲酸酯。描述了用于杀虫剂使用的各种配方以及适当的施用速率。

  公开号：

  US04201733A1

文献信息

• N-Phosphinoaminosulfinylcarbamate esters and their use as insecticides
  申请人：Regents of the University of California

  公开号：US04410518A1

  公开（公告）日：1983-10-18

  A novel class of chemical compounds useful as pesticides consists of N-phosphinoaminosulfinylcarbamate esters. The preparation of these compounds and their formulation to control insects are exemplified.

  一类新型的化学化合物作为杀虫剂很有用，它由N-磷氨基磺酰基氨基甲酸酯组成。这些化合物的制备及其用于控制昆虫的配方均有实例。
• N-[(phosphinyl or phosphinothioyl)amino]thio-methylcarbamates and
  申请人：The Upjohn Company

  公开号：US04208409A1

  公开（公告）日：1980-06-17

  Some new phosphinic acid derivatives of aminothio methylcarbamates have been synthesized and tested as pesticides. The new compounds are active against insects, mites, and nematodes. The N-[(phosphinyl)amino]thio- and N-[(phosphinothioyl)amino]thio- methylcarbamates are readily prepared by the general procedure of reacting a phosphinic acid amide with sulfur dichloride so as to obtain the corresponding N-(chlorothio)phosphinic acid amide which reactant will react with a methylcarbamate so as to produce the corresponding object compounds, the N-[(phosphinothioyl)amino]thio- methylcarbamates of this invention. Various formulations for pesticidal use are described along with appropriate rates of application.

  已合成并测试了一些新的氨硫甲酸磷酸酯衍生物作为杀虫剂。这些新化合物对昆虫、螨和线虫具有活性。N-[(磷氨基)硫基]-和N-[(磷硫酰)氨基]硫基甲基氨基甲酸酯可通过将磷酸胺与二氯化硫反应的一般程序制备，从而获得相应的N-(氯硫)磷酸胺，该反应物将与甲基氨基甲酸酯反应，从而产生本发明的相应化合物，即N-[(磷硫酰)氨基]硫基甲基氨基甲酸酯。描述了用于杀虫剂使用的各种配方以及适当的施用速率。
• N-[(phosphinyl) amino]thio- and
  申请人：The Upjohn Company

  公开号：US04081536A1

  公开（公告）日：1978-03-28

  Some new phosphinic acid derivatives of aminothio methylcarbamates have been synthesized and tested as pesticides. The new compounds are active against insects, mites, and nematodes. The N-[(phosphinyl)amino]thio- and N-[(phosphinothioyl)amino]thio- methylcarbamates are readily prepared by the general procedure of reacting a phosphinic acid amide with sulfur dichloride so as to obtain the corresponding N-(chlorothio)phosphinic acid amide which reactant will react with a methylcarbamate so as to produce the corresponding object compounds, the N-[phosphinyl)amino]thio- and N-[(phosphinothioyl)-amino]thio- methylcarbamates of this invention. Various formulations for pesticidal use are described along with appropriate rates of application.

  已合成并测试了一些新的磷酸酯类氨基硫代甲基氨基甲酸酯衍生物作为杀虫剂。这些新化合物对昆虫、螨和线虫具有活性。N-[(磷酰胺基)硫代]和N-[(磷硫酰基)胺基]硫代甲基氨基甲酸酯可通过一般程序制备，即将磷酸酯酰胺与二氯化硫反应，从而获得相应的N-(氯硫)磷酸酯酰胺，该反应物将与甲基氨基甲酸酯反应，从而产生本发明的相应化合物，即N-[(磷酰胺基)硫代]和N-[(磷硫酰基)胺基]硫代甲基氨基甲酸酯。还描述了用于杀虫剂使用的各种配方以及适当的施用速率。
• Processes for making phosphorus derivatives of aminothiomethylcarbamates
  申请人：The Upjohn Company

  公开号：US04354975A1

  公开（公告）日：1982-10-19

  This invention pertains to novel processes for preparing phosphorus derivatives of aminothiomethylcarbamates using as intermediates corresponding phosphorus derivatives of aminothiocarbamic halides. The carbamates are useful as pesticides against insects, mites, and nematodes. Two processes for preparing the corresponding intermediates are described. One preparation generally reacts an appropriate N-chlorothiophosphoramide with N-methylcarbamoyl halide. The other preparation generally reacts an N-chlorothiomethylcarbamoyl halide with an appropriate phosphoramide. The intermediate will react with various alcohols to produce the desired carbamates in the process of the invention.

  本发明涉及使用相应的氨硫代氨基卡巴酸酯的磷衍生物作为中间体，制备氨硫代卡巴酸酯的新工艺。这些卡巴酸酯可用作杀虫剂，用于对抗昆虫、螨和线虫。文中描述了两种制备相应中间体的方法。一种制备方法通常是将适当的N-氯硫代磷酰胺与N-甲基氨基卡巴酰卤反应。另一种制备方法通常是将N-氯硫代甲基卡巴酰卤与适当的磷酰胺反应。该中间体将与各种醇反应，从而在本发明的过程中产生所需的卡巴酸酯。
• Phosphorus derivatives of aminothiocarbamoyl halides
  申请人：The Upjohn Company

  公开号：US04234521A1

  公开（公告）日：1980-11-18

  This invention pertains to novel phosphorus derivatives of aminothiocarbamic halides and processes for their preparation. The carbamic halides are readily prepared by two general procedures. In one procedure an appropriate N-(chlorothio)phosphorus amide reactant is readily prepared by reacting the corresponding phosphorus amide with sulfur dichloride which reactant will react with N-methylcarbamoyl halide so as to produce the corresponding object compounds of this invention. In a different procedure the same compounds that are the object of this invention are prepared by reacting an appropriate corresponding phosphorus amide with an N-chlorothiomethylcarbamoyl halide reactant which reactant is readily prepared by reacting N-methylcarbamoyl halide with sulfur chloride. The novel compounds of this invention are intermediates for the preparation of pesticides.

  这项发明涉及新型的氨基硫代氨基卡巴酸卤化物磷衍生物及其制备方法。卡巴酸卤化物可以通过两种一般程序轻松制备。在一种程序中，通过将相应的磷酰胺与二氯化硫反应，可以轻松制备适当的N-(氯硫)磷酰胺试剂，该试剂将与N-甲基氨基甲酰卤化物反应，从而产生本发明的相应目标化合物。在另一种程序中，通过将适当的相应磷酰胺与N-氯硫甲基氨基甲酰卤化物试剂反应，可以制备本发明的相同化合物，该试剂可以通过将N-甲基氨基甲酰卤化物与硫氯化物反应来轻松制备。本发明的新型化合物是制备农药的中间体。