2-氨基-1,2,3,4-四氢-1-萘甲酸 | 103796-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-氨基-1,2,3,4-四氢-1-萘甲酸
• 英文名称: 2-Amino-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
• CAS: 103796-56-1
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: RZFVSHCAXBGXHO-UHFFFAOYSA-N

物化性质

• 熔点：
  138 °C
• 沸点：
  379.7±42.0 °C(Predicted)
• 密度：
  1.225±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Transporting of taxoid derivatives through the blood brain barrier
  申请人：Temsamani Jamal

  公开号：US20060293242A1

  公开（公告）日：2006-12-28

  Taxoid derivatives are used in the treatment of cancers, particular cancers of the central nervous system, such as brain cancers. Taxoid derivatives are transported across the blood/brain barrier (BBB). A compound is provided which consists of at least one taxoid derivative bound to at least one vector peptide capable of increasing the solubility of the derivative and advantageously allowing it to be transported across the BBB.

  紫杉醇衍生物被用于治疗癌症，特别是中枢神经系统的癌症，如脑癌。紫杉醇衍生物可跨越血脑屏障（BBB）。提供一种化合物，其中包含至少一种紫杉醇衍生物与至少一种载体肽结合，能够增加衍生物的溶解度，并有利地使其跨越BBB。
• Spiro compounds, their production and use
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0670313A1

  公开（公告）日：1995-09-06

  A compound represented by the formula: wherein ring A represents an optionally substituted aromatic ring; T represents an optionally substituted hydrogen atom or an optionally substituted hydrocarbon group; X represents -CH₂-, -CO- or -CH(OH)-; D represents - CH₂-, -O- or -NR- wherein R is a hydrogen atom or an optionally substituted hydrocarbon group and m, e and f independently represent an integer from 1 to 3, or a salt thereof, which excellently inhibits a monoamine uptake, monoamine oxidase B and/or Ca ion uptake, and is useful as a prophylactic and therapeutic drug for a central nervous diseases.

  由式表示的化合物： 其中环 A 代表任选取代的芳环；T 代表任选取代的氢原子或任选取代的烃基；X 代表 -CH₂-、-CO- 或 -CH(OH)-；D代表-CH₂-、-O-或-NR-，其中R为氢原子或任选取代的烃基，m、e和f独立地代表1至3的整数，或其盐，可有效抑制单胺摄取、单胺氧化酶B和/或钙离子摄取，可用作中枢神经疾病的预防和治疗药物。
• Compounds comprising an analgesic molecule linked to a vector that can vectorise said molecule through the hematoencephalic barrier and pharmaceutical compositions containing same
  申请人：——

  公开号：US20040248806A1

  公开（公告）日：2004-12-09

  The invention relates to compounds comprising an analgesic molecule which is selected from morphine and the derivatives and metabolites thereof and which is vectorised by means of its link to a vector such that the analgesic molecule passes through the hematoencephalic barrier. The invention also relates to the use of the compounds for the preparation of medicaments that are used to treat pain.

  本发明涉及由镇痛分子组成的化合物，该分子选自吗啡及其衍生物和代谢物，并通过与载体的连接被载体化，从而使镇痛分子通过血脑屏障。本发明还涉及使用这些化合物制备治疗疼痛的药物。
• RESIST PATTERN THICKENING MATERIAL, SEMICONDUCTOR DEVICE, AND PRODUCTION METHOD THEREOF
  申请人：KOZAWA Miwa

  公开号：US20110101508A1

  公开（公告）日：2011-05-05

  A resist pattern thickening material containing a resin, a cyclic compound expressed by the general formula 1, at least one of compounds expressed by the general formulae 2 to 3, respectively, and water:
• US5591849A
  申请人：——

  公开号：US5591849A

  公开（公告）日：1997-01-07