3-(2-trityloxy-phenyl)-3H-imidazole-4-carboxylic acid | 936843-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 3-(2-trityloxy-phenyl)-3H-imidazole-4-carboxylic acid
• 英文别名: 3-(2-Trityloxyphenyl)imidazole-4-carboxylic acid
• CAS: 936843-07-1
• 化学式: C₂₉H₂₂N₂O₃
• 分子量: 446.505
• InChiKey: ZINUXWKKBUQRTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2-trityloxy-phenyl)-3H-imidazole-4-carboxylic acid 在 草酰氯 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 3-(2-Trityloxyphenyl)imidazole-4-carbonyl chloride
  参考文献：
  名称：

  Syntheses of Hemoprotein Models that can be Covalently Attached onto Electrode Surfaces by Click Chemistry

  摘要：

  Five alkyne-containing hemoprotein models have been synthesized in a convergent manner. Sonogashira coupling was used to introduce the alkyne functional group on the proximal imidazole before or after being attached on the porphyrin. One model was immobilized onto a gold electrode surface via copper(I)-catalyzed azide-alkyne cycloaddition (Sharpless click chemistry).

  DOI：

  10.1021/jo062349w
• 作为产物：
  描述：

  Ethyl 1-(o-hydroxyphenyl)imidazole-5-carboxylate 在 sodium hydroxide 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 27.0h， 生成 3-(2-trityloxy-phenyl)-3H-imidazole-4-carboxylic acid
  参考文献：
  名称：

  Syntheses of Hemoprotein Models that can be Covalently Attached onto Electrode Surfaces by Click Chemistry

  摘要：

  Five alkyne-containing hemoprotein models have been synthesized in a convergent manner. Sonogashira coupling was used to introduce the alkyne functional group on the proximal imidazole before or after being attached on the porphyrin. One model was immobilized onto a gold electrode surface via copper(I)-catalyzed azide-alkyne cycloaddition (Sharpless click chemistry).

  DOI：

  10.1021/jo062349w

文献信息

• Syntheses of Hemoprotein Models that can be Covalently Attached onto Electrode Surfaces by Click Chemistry
  作者：Richard A. Decréau、James P. Collman、Ying Yang、Yilong Yan、Neal K. Devaraj

  DOI：10.1021/jo062349w

  日期：2007.4.1

  Five alkyne-containing hemoprotein models have been synthesized in a convergent manner. Sonogashira coupling was used to introduce the alkyne functional group on the proximal imidazole before or after being attached on the porphyrin. One model was immobilized onto a gold electrode surface via copper(I)-catalyzed azide-alkyne cycloaddition (Sharpless click chemistry).