ethyl 4-(ethylnaphthylamino)butanoate | 500758-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ethyl 4-(ethylnaphthylamino)butanoate
• 英文别名: ethyl 4-[ethyl(naphthalen-1-yl)amino]butanoate
• CAS: 500758-39-4
• 化学式: C₁₈H₂₃NO₂
• 分子量: 285.386
• InChiKey: KKTSGSBRKBCBIX-UHFFFAOYSA-N

物化性质

• 沸点：
  405.2±28.0 °C(Predicted)
• 密度：
  1.080±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-溴丁酸乙酯 、 α-乙基氨基萘 在 N,N-二异丙基乙胺 作用下， 生成 ethyl 4-(ethylnaphthylamino)butanoate
  参考文献：
  名称：

  Non-fluorescent quencher compounds and biomolecular assays

  摘要：

  双重重氮基、三芳基和芳基重氮-N-芳基苯酚盐猝灭基团，通过带电子吸引和电子给予取代基团引起芳基/重氮环系统极性，当连接到生物分子如多核苷酸、核苷、核苷酸和多肽时，可作为标签。这些猝灭基团是非荧光的，并通过任何能量转移机制（如FRET）从荧光报告标签吸收能量。荧光猝灭剂组合物在制备带有猝灭剂标记的生物分子，用于基于荧光检测的各种分子生物学分析中，非常有用。

  公开号：

  US20030082547A1

文献信息

• NON-FLUORESCENT QUENCHER COMPOUNDS AND BIOMOLECULAR ASSAYS
  申请人：EWING Gregory J.

  公开号：US20090105452A1

  公开（公告）日：2009-04-23

  Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides and polypeptides. The quencher moieties are non-fluorescent and accept energy transfer from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labeled biomolecules for various molecular biology assays based on fluorescence detection.

  双重重氮基团、三芳基和芳基重氮-N-芳基苯唑啉猝灭基团，通过在离域芳基/重氮环系统中引入电子受体和电子供体取代基，可以作为标签附加到生物分子上，如多核苷酸、核苷、核苷酸和多肽。这些猝灭基团是非荧光的，可以通过任何能量转移机制（例如FRET）从荧光报告标签接受能量转移。荧光猝灭剂组合物在制备标记生物分子的过程中非常有用，用于各种基于荧光检测的分子生物学测定。
• Non-Fluorescent Quencher Compounds and Biomolecular Assays
  申请人：Ewing Gregory J.

  公开号：US20110245462A1

  公开（公告）日：2011-10-06

  Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides and polypeptides. The quencher moieties are non-fluorescent and accept energy transfer from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labeled biomolecules for various molecular biology assays based on fluorescence detection.

  双重重氮基团、三芳基和芳基重氮基-N-芳基苯并咪唑猝灭基团，通过引入电子吸引和电子给予取代基来诱导离域芳基/重氮环系统的极性，当附加到生物分子如多核苷酸、核苷、核苷酸和多肽时，它们可用作标签。猝灭基团是无荧光的，并且通过任何能量转移机制（如FRET），从荧光报告标签接受能量转移。荧光猝灭组合物在制备带有猝灭标记的生物分子用于基于荧光检测的各种分子生物学测定中非常有用。
• US8637658B2
  申请人：——

  公开号：US8637658B2

  公开（公告）日：2014-01-28
• [EN] NON-FLUORESCENT QUENCHER COMPOUNDS AND BIOMOLECULAR ASSAYS<br/>[FR] COMPOSES EXTINCTEURS NON-FLUORESCENTS ET TESTS BIOMOLECULAIRES
  申请人：APPLERA CORP

  公开号：WO2003019145A2

  公开（公告）日：2003-03-06

  Bis-diazo,triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides, and polypeptides. The quencher moieties are non-fluorescent and accept energy from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labelled biomolecules for various molecular biology assays based on fluorescence detection.
• Non-fluorescent quencher compounds and biomolecular assays
  申请人：——

  公开号：US20030082547A1

  公开（公告）日：2003-05-01

  Bis-diazo,triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides, and polypeptides. The quencher moieties are non-fluorescent and accept energy from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labelled biomolecules for various molecular biology assays based on fluorescence detection. 1

  双重重氮基、三芳基和芳基重氮-N-芳基苯酚盐猝灭基团，通过带电子吸引和电子给予取代基团引起芳基/重氮环系统极性，当连接到生物分子如多核苷酸、核苷、核苷酸和多肽时，可作为标签。这些猝灭基团是非荧光的，并通过任何能量转移机制（如FRET）从荧光报告标签吸收能量。荧光猝灭剂组合物在制备带有猝灭剂标记的生物分子，用于基于荧光检测的各种分子生物学分析中，非常有用。