2,6-Diamino-4-methylfuro[2,3-f][1]benzofuran-3,7-dicarbonitrile | 1274703-46-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2,6-Diamino-4-methylfuro[2,3-f][1]benzofuran-3,7-dicarbonitrile
• CAS: 1274703-46-6
• 化学式: C₁₃H₈N₄O₂
• 分子量: 252.232
• InChiKey: HOJCYBCYPBYEFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲基氢醌 、 丙二腈 以 水 为溶剂， 以68%的产率得到2,6-Diamino-4-methylfuro[2,3-f][1]benzofuran-3,7-dicarbonitrile
  参考文献：
  名称：

  Electro-Organic Synthesis of 2-Amino-3-cyano-benzofuran Derivatives Using Hydroquinones and Malononitrile

  摘要：

  [image omitted] In this work, electrochemical oxidation of hydroquinones has been studied in the presence of malononitrile as a nucleophile in aqueous solution using cyclic voltammetry and controlled potential coulometry. The results indicate that the quinones derived from hydroquinones participate in Michael addition and then intramolecular nucleophilic addition to yield benzofuran derivatives. The electrochemical synthesis of these new 2-amino-3-cyano-benzofuran derivatives has been performed successfully at a carbon-rod electrode in an undivided cell in good to excellent yields at room temperature.

  DOI：

  10.1080/00397911003629424

文献信息

• Electro-Organic Synthesis of 2-Amino-3-cyano-benzofuran Derivatives Using Hydroquinones and Malononitrile
  作者：Ali Reza Fakhari、Hamid Ahmar、Saied Saeed Hosseiny Davarani、Ahmad Shaabani、Sanaz Nikjah、Ali Maleki

  DOI：10.1080/00397911003629424

  日期：2011.1.31

  [image omitted] In this work, electrochemical oxidation of hydroquinones has been studied in the presence of malononitrile as a nucleophile in aqueous solution using cyclic voltammetry and controlled potential coulometry. The results indicate that the quinones derived from hydroquinones participate in Michael addition and then intramolecular nucleophilic addition to yield benzofuran derivatives. The electrochemical synthesis of these new 2-amino-3-cyano-benzofuran derivatives has been performed successfully at a carbon-rod electrode in an undivided cell in good to excellent yields at room temperature.