cis-3-ethyl-4-methylpiperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: cis-3-ethyl-4-methylpiperidine
• 英文别名: 3-ethyl-4-methylpiperidine；(3S,4S)-3-ethyl-4-methylpiperidine
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: SORSGGFKUBXRQA-JGVFFNPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (S:R)-N-benzyl-1,1'-iminobis-2-butanol 在 palladium on activated charcoal 硫酸 、 氢气 作用下， 以 1,4-二氧六环 为溶剂， 80.0~145.0 ℃ 、10.34 MPa 条件下， 反应 24.0h， 生成 cis-3-ethyl-4-methylpiperidine
  参考文献：
  名称：

  Hernestam, Sven, Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 1681 - 1685

  摘要：

  DOI：

文献信息

• SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD
  申请人：Cheng T. W. Peter

  公开号：US20070287713A1

  公开（公告）日：2007-12-13

  wherein Z 1 is (CH 2 ) q or C═O; Z 2 is (CH 2 ) p or C═O; D is —CH═ or C═O or (CH 2 ) m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; A is (CH 2 ) x where x is 1 to 5, or A is (CH 2 ) x 1 , where x 1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is —(CH 2 ) x 2 —O—(CH 2 ) x 3 — where x 2 is 0 to 5 and x 3 is 0 to 5, provided that at least one of x 2 and x 3 is other than 0; B is a bond or is (CH 2 ) x 4 where x 4 is 1 to 5; X is CH or N; X 2 is C, N, O or S; X 3 is C, N, O or S; X 4 is C, N, O or S; X 5 is C, N, O or S; X 6 is C, N, O or S; provided that at least one of X 2 , X 3 , X 4 X 5 and X 6 is N; and at least one of X 2 , X 3 , X 4 X 5 and X 6 is C. R 1 is H or alkyl; R 2 is H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; R 2a , R 2b and R 2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; and R 3 , E, Z and Y are as defined herein.

  其中Z1为(CH2)q或C═O；Z2为(CH2)p或C═O；D为—CH═或C═O或(CH2)m，其中m为0、1、2或3；n=0、1或2；p=1或2；q=0、1或2；Q为C或N；A为(CH2)x，其中x为1到5，或A为(CH2)x1，其中x1为1到5，具有烯丙基键或炔基键嵌入链中的任何位置，或A为—(CH2)x2—O—(CH2)x3—，其中x2为0到5，x3为0到5，前提是x2和x3中至少有一个不为0；B为键或(CH2)x4，其中x4为1到5；X为CH或N；X2、X3、X4、X5和X6为C、N、O或S；前提是X2、X3、X4、X5和X6中至少有一个为N；并且X2、X3、X4、X5和X6中至少有一个为C。R1为H或烷基；R2为H、烷基、烷氧基、卤素、氨基、取代氨基或氰基；R2a、R2b和R2c可以相同也可以不同，选择自H、烷基、烷氧基、卤素、氨基、取代氨基或氰基；而R3、E、Z和Y的定义如前所述。
• Hernestam, Sven; Stenvall, Gillis; Olsson, Thomas, Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 647 - 651
  作者：Hernestam, Sven、Stenvall, Gillis、Olsson, Thomas

  DOI：——

  日期：——
• CYCLIN-DEPENDENT KINASE INHIBITORS
  申请人：SPV THERAPEUTICS INC.

  公开号：US20220056037A1

  公开（公告）日：2022-02-24

  Described herein are compounds and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, methods of treatment, and medical uses. The compounds described herein are modulators of cyclin-dependent kinases, and are useful in the treatment or alleviation of protein kinase associated disorders, including cancer, infectious diseases, autoimmune diseases, or cardiovascular diseases.
• US7279485B2
  申请人：——

  公开号：US7279485B2

  公开（公告）日：2007-10-09
• US7951793B2
  申请人：——

  公开号：US7951793B2

  公开（公告）日：2011-05-31