1-(2-Chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea | 497149-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2-Chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
• CAS: 497149-28-7
• 化学式: C₁₇H₁₃ClN₂O₂
• 分子量: 312.755
• InChiKey: ZZRAIFAJILLITB-UHFFFAOYSA-N

物化性质

• 沸点：
  429.9±25.0 °C(Predicted)
• 密度：
  1.459±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-氨基-7-萘酚 、 1,2,4-三氯萘 以 1,4-二氧六环 为溶剂， 反应 3.0h， 生成 1-(2-Chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
  参考文献：
  名称：

  Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary incontinence

  摘要：

  We have identified naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 by high throughput screening. The initial lead showed high clearance in rats and has been optimized by enhancing the acidity of the phenol group. Compound 6b has reduced clearance, improved potency and is active in rat cystometry models of urinary incontinence after intravenous administration. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.013

文献信息

• Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary incontinence
  作者：Klaus Urbahns、Takeshi Yura、Muneto Mogi、Masaomi Tajimi、Hiroshi Fujishima、Tsutomu Masuda、Nagahiro Yoshida、Toshiya Moriwaki、Timothy B. Lowinger、Heinrich Meier、Fiona Chan、David Madge、Jang B. Gupta

  DOI：10.1016/j.bmcl.2011.04.013

  日期：2011.6

  We have identified naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 by high throughput screening. The initial lead showed high clearance in rats and has been optimized by enhancing the acidity of the phenol group. Compound 6b has reduced clearance, improved potency and is active in rat cystometry models of urinary incontinence after intravenous administration. (C) 2011 Elsevier Ltd. All rights reserved.