N-<2-<4-(4-chlorophenyl)-1-piperazinyl>ethyl>-4-fluorobenzamide | 27227-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-<2-<4-(4-chlorophenyl)-1-piperazinyl>ethyl>-4-fluorobenzamide
• 英文别名: 4-fluoro-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)benzamide；4-fluoro-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]benzamide
• CAS: 27227-14-1
• 化学式: C₂₀H₂₄FN₃O₂
• 分子量: 357.428
• InChiKey: GTATVXRFYOQYFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Phenylpiperazine derivatives and process for producing the same
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP0104614B1

  公开（公告）日：1986-12-30
• 5 HT RECEPTOR MEDIATED NEUROGENESIS
  申请人：Barlow Carrolee

  公开号：US20100009983A1

  公开（公告）日：2010-01-14

  The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a 5HTR agent, in combination with one or more other neurogenic agents, or anti-astrogenic agent, to stimulate or activate the formation of new nerve cells.