1,4-diphenyl-piperidine-2,6-dione | 54946-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,4-diphenyl-piperidine-2,6-dione
• 英文别名: 1,4-Diphenyl-piperidin-2,6-dion；3,6-Diphenyl-glutarimid；1,4-Diphenylpiperidine-2,6-dione
• CAS: 54946-32-6
• 化学式: C₁₇H₁₅NO₂
• mdl: MFCD02679753
• 分子量: 265.312
• InChiKey: KFVVVXVEQMFLQS-UHFFFAOYSA-N

物化性质

• 熔点：
  222-223 °C
• 沸点：
  497.9±34.0 °C(Predicted)
• 密度：
  1.212±0.06 g/cm3(Predicted)
• 溶解度：
  11.3 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-diphenyl-piperidine-2,6-dione 在 bis(2,6-dimethylphenoxy)borane 、 diethylzinc 、 (1R,2S)-(-)-1-phenyl-2-piperidinopropane-1-thiol 作用下， 生成 6-Hydroxy-1,4-diphenyl-piperidin-2-one
  参考文献：
  名称：

  Asymmetric catalytic reduction of meso-imides

  摘要：

  A thiazazincolidine complex, 1, was shown to be an excellent catalyst for enantioselective reduction with bis(2,6-dimethylphenoxy)borane (BDMPB) of meso N-phenylimides in high ee to the corresponding hydroxy lactams, which were eventually converted to the corresponding lactones of high optical purity.

  DOI：

  10.1016/0040-4039(95)00728-u
• 作为产物：
  描述：

  5-(phenylamino)-5-oxo-3-phenylpentanoic acid 生成 1,4-diphenyl-piperidine-2,6-dione
  参考文献：
  名称：

  Avery; Bouton, American Chemical Journal, 1898, vol. 20, p. 513

  摘要：

  DOI：

文献信息

• Mallard; Wilson, Journal of the American Pharmaceutical Association (1912), 1957, vol. 46, p. 176
  作者：Mallard、Wilson

  DOI：——

  日期：——
• Avery; Bouton, American Chemical Journal, 1898, vol. 20, p. 513
  作者：Avery、Bouton

  DOI：——

  日期：——
• Asymmetric catalytic reduction of meso-imides
  作者：Jahyo Kang、Jun Won Lee、Joo In Kim、Chongsuh Pyun

  DOI：10.1016/0040-4039(95)00728-u

  日期：1995.6

  A thiazazincolidine complex, 1, was shown to be an excellent catalyst for enantioselective reduction with bis(2,6-dimethylphenoxy)borane (BDMPB) of meso N-phenylimides in high ee to the corresponding hydroxy lactams, which were eventually converted to the corresponding lactones of high optical purity.