3-tert-butyloxycarbonyl-7-(5-hydroxypentyl)-9-oxo-3,7-diazabicyclo[3.3.1]nonane | 612092-86-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-tert-butyloxycarbonyl-7-(5-hydroxypentyl)-9-oxo-3,7-diazabicyclo[3.3.1]nonane
• 英文别名: Tert-butyl 7-(5-hydroxypentyl)-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate；tert-butyl 7-(5-hydroxypentyl)-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
• CAS: 612092-86-1
• 化学式: C₁₇H₃₀N₂O₄
• 分子量: 326.436
• InChiKey: LRTZGGYFZJTGHL-UHFFFAOYSA-N

物化性质

• 沸点：
  469.2±45.0 °C(predicted)
• 密度：
  1.121±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-tert-butyloxycarbonyl-7-(5-hydroxypentyl)-9-oxo-3,7-diazabicyclo[3.3.1]nonane 在 sodium tetrahydroborate 、 对甲苯磺酰肼 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 5.0h， 生成 3-tert-butyloxycarbonyl-7-(5-hydroxypentyl)-3,7-diazabicyclo[3.3.1]nonane
  参考文献：
  名称：

  New solution free and polymer anchored chiral bispidine-based amino alcohols. Synthesis and screening for the enantioselective addition of diethylzinc to benzaldehyde

  摘要：

  A new approach has been evaluated for the preparation of solution free and polymer supported chiral bicyclic amino alcohols. This strategy involves the use of readily available starting materials and allows chiral ligands characterised by the bispidine core. bearing a stereogenic centre beta to one of the nitrogen atoms to be obtained. The first results obtained from the application of these ligands in the asymmetric addition reaction of diethylzinc to benzaldehyde are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00483-x
• 作为产物：
  描述：

  聚合甲醛 、 5-氨基-1-戊醇 、 N-叔丁氧羰基-4-哌啶酮 在 盐酸 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以57%的产率得到3-tert-butyloxycarbonyl-7-(5-hydroxypentyl)-9-oxo-3,7-diazabicyclo[3.3.1]nonane
  参考文献：
  名称：

  New solution free and polymer anchored chiral bispidine-based amino alcohols. Synthesis and screening for the enantioselective addition of diethylzinc to benzaldehyde

  摘要：

  A new approach has been evaluated for the preparation of solution free and polymer supported chiral bicyclic amino alcohols. This strategy involves the use of readily available starting materials and allows chiral ligands characterised by the bispidine core. bearing a stereogenic centre beta to one of the nitrogen atoms to be obtained. The first results obtained from the application of these ligands in the asymmetric addition reaction of diethylzinc to benzaldehyde are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00483-x

文献信息

• New solution free and polymer anchored chiral bispidine-based amino alcohols. Synthesis and screening for the enantioselective addition of diethylzinc to benzaldehyde
  作者：Giordano Lesma、Bruno Danieli、Daniele Passarella、Alessandro Sacchetti、Alessandra Silvani

  DOI：10.1016/s0957-4166(03)00483-x

  日期：2003.8

  A new approach has been evaluated for the preparation of solution free and polymer supported chiral bicyclic amino alcohols. This strategy involves the use of readily available starting materials and allows chiral ligands characterised by the bispidine core. bearing a stereogenic centre beta to one of the nitrogen atoms to be obtained. The first results obtained from the application of these ligands in the asymmetric addition reaction of diethylzinc to benzaldehyde are discussed. (C) 2003 Elsevier Ltd. All rights reserved.