5-Diphenylmethyl-2-hydroxy-benzoesaeure | 94465-14-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5-Diphenylmethyl-2-hydroxy-benzoesaeure
• 英文别名: 5-Benzhydryl-2-hydroxybenzoic acid
• CAS: 94465-14-2
• 化学式: C₂₀H₁₆O₃
• 分子量: 304.345
• InChiKey: IYIQDSOUUVOQFU-UHFFFAOYSA-N

物化性质

• 熔点：
  143-144 °C
• 沸点：
  475.7±45.0 °C(Predicted)
• 密度：
  1.249±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴水杨酸 在 palladium on activated charcoal 氢气 、 叔丁基锂 作用下， 反应 1.0h， 生成 5-Diphenylmethyl-2-hydroxy-benzoesaeure
  参考文献：
  名称：

  Lithiation of polyhydric compounds. Salicylic acids

  摘要：

  Polylithiated derivatives of salicylic and oligosalicylic acids can be generated by means of the halogen-to-metal exchange reaction. Dehydrobromination and other byproducts can be kept to a minimum by working with the preformed lithium salts which are soluble in THF. Even base sensitive salicylic acids such as 6-bromolasalocid acid can be functionalized under these conditions.

  DOI：

  10.1021/jo00067a048

文献信息

• US4219219A
  申请人：——

  公开号：US4219219A

  公开（公告）日：1980-08-26
• Lithiation of polyhydric compounds. Salicylic acids
  作者：M. Carmen Rotger、Antoni Costa、Jose M. Saa

  DOI：10.1021/jo00067a048

  日期：1993.7

  Polylithiated derivatives of salicylic and oligosalicylic acids can be generated by means of the halogen-to-metal exchange reaction. Dehydrobromination and other byproducts can be kept to a minimum by working with the preformed lithium salts which are soluble in THF. Even base sensitive salicylic acids such as 6-bromolasalocid acid can be functionalized under these conditions.