benzofuroxane N-oxide | 236092-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: benzofuroxane N-oxide
• 英文别名: 1-Oxido-2,1,3-benzoxadiazol-3-ium 3-oxide
• CAS: 236092-93-6
• 化学式: C₆H₄N₂O₃
• 分子量: 152.109
• InChiKey: SOOVOQYNAKADEE-UHFFFAOYSA-N

物化性质

• 沸点：
  307.3±25.0 °C(Predicted)
• 密度：
  1.60±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzofuroxane N-oxide 在 sodium dithionite 、 三乙胺 作用下， 以 甲醇 、 水 为溶剂， 反应 0.17h， 生成 1-(3-甲基喹喔啉-2-基)乙酮
  参考文献：
  名称：

  Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti-Inflammatory Agents

  摘要：

  We report the synthesis, anti‐inflammatory, and antioxidant activities of novel quinoxaline and quinoxaline 1,4‐di‐N‐oxide derivatives. Microwave‐assisted methods have been used to optimize reaction times and to improve yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase (LOX). Two of the best LOX inhibitors (compounds 7b and 8f) were evaluated as in vivo anti‐inflammatory agents using the carrageenin‐induced edema model. One of them (compound 7b) showed important in vivo anti‐inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug.

  DOI：

  10.1111/j.1747-0285.2011.01076.x

文献信息

• Compositions for use in golf balls
  申请人：Bulpett A. David

  公开号：US20050245652A1

  公开（公告）日：2005-11-03

  A golf ball comprises a core, an outer cover layer, and, optionally, an intermediate layer disposed between the core and the outer cover layer. The outer cover layer may comprise a polyurethane or polyurea composition. At least one portion of the golf ball comprises a composition that enhances physical properties and/or performance characteristics (e.g., coefficient of restitution) of the golf ball. Preferably, the coefficient of restitution of the core is 0.8 or greater.

  高尔夫球由内核、外覆盖层和可选的中间层组成，外覆盖层可以包括聚氨酯或聚脲组成。高尔夫球的至少一部分包含一种增强物理特性和/或性能特征（例如反弹系数）的组合物。最好，内核的反弹系数为0.8或更高。
• COMPOSITIONS FOR USE IN GOLF BALLS
  申请人：Sullivan Michael J.

  公开号：US20080227567A1

  公开（公告）日：2008-09-18

  A golf ball comprises a core, an outer cover layer, and, optionally, an intermediate layer disposed between the core and the outer cover layer. The outer cover layer may comprise a polyurethane or polyurea composition. At least one portion of the golf ball comprises a composition that enhances physical properties and/or performance characteristics (e.g., coefficient of restitution) of the golf ball. Preferably, the coefficient of restitution of the core is 0.8 or greater.

  一个高尔夫球包括一个核心、一个外覆盖层，以及可选的介质层，介质层位于核心和外覆盖层之间。外覆盖层可能包括聚氨酯或聚脲组成。高尔夫球的至少一部分包含一种增强高尔夫球物理性能和/或性能特征（例如反弹系数）的组成。最好，核心的反弹系数为0.8或更高。
• Compositions for Use in Golf Balls
  申请人：Bulpett David A.

  公开号：US20080176678A1

  公开（公告）日：2008-07-24

  A golf ball comprising a core and at least one layer disposed about the core, wherein at least one of the core or the layer is formed from a composition comprising a base polymer, a crosslink initiator, and an additive comprising an aromatic iodonium compound or an aromatic iodonium salt.

  一颗高尔夫球包括一个核心和至少一层沿核心排列的材料，其中核心或层中的至少一个是由包含基础聚合物、交联引发剂和添加剂的组合物形成的，该添加剂包括芳香碘化物或芳香碘化盐。
• [EN] BENZOFUROXAN OXIDE HISTONE DEACETYLASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF<br/>[FR] INHIBITEUR DES HISTONE DÉSACÉTYLASES DE TYPE BENZOFUROXAN OXIDE, MÉTHODE DE PRÉPARATION ET UTILISATION CORRESPONDANTES<br/>[ZH] 一种苯并氧化呋咱组蛋白去乙酰化酶抑制剂及其制备方法和应用
  申请人：UNIV SHANDONG

  公开号：WO2016112768A1

  公开（公告）日：2016-07-21

  本发明涉及一种苯并呋咱氧化物组蛋白去乙酰化酶抑制剂及其制备方法和应用。所述化合物具有式I或Ⅰ'的结构，通式I的互变异构体II或通式Ⅰ'的互变异构体II'。本发明还涉及含有式I，Ⅰ'，II，II'结构化合物的药物组合物。本发明的化合物，用于制备预防或治疗与组蛋白去乙酰化酶活性异常表达相关的哺乳动物疾病的药物。
• YAMASITA, AKIRA;XADANO, TOSIO;NUMAMOTO, KIESI
  作者：YAMASITA, AKIRA、XADANO, TOSIO、NUMAMOTO, KIESI

  DOI：——

  日期：——