1,4-naphthoquinone-2-sulfonic acid, potassium salt | 34169-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,4-naphthoquinone-2-sulfonic acid, potassium salt
• 英文别名: 1,4-naphthoquinone-2-sulfonic acid potassium salt；2-Potassium sulfonate-naphthoquinone；potassium 1,4-dihydro-1,4-dioxonaphthalene-2-sulphonate；1,4-Naphthochinon-2-sulfonsaeure；2-Naphthalenesulfonic acid, 1,4-dihydro-1,4-dioxo-, potassium salt；potassium;1,4-dioxonaphthalene-2-sulfonate
• CAS: 34169-62-5
• 化学式: C₁₀H₅O₅S*K
• 分子量: 276.311
• InChiKey: WZEGLRXCWYMIDO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.7
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2914399090

反应信息

• 作为反应物：
  描述：

  1,4-naphthoquinone-2-sulfonic acid, potassium salt 、 苯胺 生成 2-Anilino-3-sulfonyl-naphthochinon-1,4
  参考文献：
  名称：

  Synthesis of some 1,4-naphthoquinones and reactions relating to their use in the study of bacterial growth inhibition

  摘要：

  合成了一系列107种1,4-萘醌和相关产物，以研究它们在抑制细菌生长中的作用方式。已经研究了其中一些与苯胺、正丁胺、甲氧基钠和正丁硫醇-三乙胺混合物的体外反应。合成了一系列C-2单取代和C-2、C-3双取代1,4-萘醌的环氧化物，并研究了它们与胺、硫醇和卤素酸的反应。这些醌类化合物中许多的紫外吸收极值也已列出。

  DOI：

  10.1139/v68-309
• 作为产物：
  描述：

  1,4-萘醌 以79%的产率得到
  参考文献：
  名称：

  CHECHEL, P. S.;GAGARINOVA, E. P.

  摘要：

  DOI：

文献信息

• IDO Inhibitors
  申请人：Mautino Mario

  公开号：US20110053941A1

  公开（公告）日：2011-03-03

  Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

  目前提供以下方法：(a) 通过接触本文中描述的化合物的调节有效量与吲哚胺2,3-二氧化酶相互作用，从而调节吲哚胺2,3-二氧化酶的活性；(b) 治疗需要吲哚胺2,3-二氧化酶(IDO)介导的免疫抑制的患者，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(c) 治疗需要抑制吲哚胺-2,3-二氧化酶酶活性的医疗状况，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(d) 增强抗癌治疗的有效性，包括给予抗癌剂和本文中描述的化合物；(e) 治疗与癌症相关的肿瘤特异性免疫抑制，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(f) 治疗与传染病相关的免疫抑制，例如HIV-1感染，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量。
• METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS
  申请人：Robert Bosch GmbH

  公开号：US20160025671A1

  公开（公告）日：2016-01-28

  Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

  本发明涉及用于生物传感器的装置和方法，该生物传感器包括多个测试位点的多位点阵列，该装置和方法可用于通过调节生物传感器中电极附近的pH或离子梯度来调节（生物分子）探针或检测剂与感兴趣的分析物之间的结合相互作用。本发明提供了适用于在生物缓冲液中改变缓冲液pH的电化学活性剂。使用该电化学活性剂改变生物缓冲液pH的方法。提供了调节生物传感器中结合相互作用的方法，以及更准确地控制和测量生物传感器中电极附近的pH或离子梯度的分析方法，以及更准确地测量生物样品中感兴趣分析物的分析方法。
• METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS, AND BUBBLE DETECTION USING ELECTRODES
  申请人：Robert Bosch GmbH

  公开号：US20160003763A1

  公开（公告）日：2016-01-07

  Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

  本发明涉及一种用于生物传感器的多位点测试位阵列的设备和方法，该设备和方法可通过调节生物传感器中电极附近的pH或离子梯度来调节（生物分子）探针或检测剂与感兴趣的生物分子分析物之间的结合相互作用。本发明还提供了一种适用于生物缓冲液的电化学活性试剂，用于改变生物缓冲液的pH。本发明还提供了使用电化学活性试剂改变生物缓冲液pH的方法。本发明提供了调节生物传感器中结合相互作用的方法，以及更准确地控制和测量生物传感器中电极附近的pH或离子梯度的分析方法，以及更准确地测量生物样品中感兴趣的分析物的分析方法。
• Process for preparation of electrophoresis gel material
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0169397A1

  公开（公告）日：1986-01-29

  Describes a process for controlling the polymerization and cross-linked density of electrophoretic gel products useful for separation of bioorganic molecules, which process utilizes photoinitiation. Photoinitiated polymerized gels afford the desired advantages of being ultra thin and having a high electrophoretic resolution with programmable porosity profiles.

  描述了一种控制用于分离生物有机分子的电泳凝胶产品的聚合和交联密度的工艺，该工艺利用了光引发技术。光引发聚合凝胶具有超薄、电泳分辨率高、孔隙率曲线可编程等优点。
• DEVICE AND METHOD FOR ACCURATE PH MONITORING ON TRANSPARENT MICROARRAYS
  申请人：Robert Bosch GmbH

  公开号：EP3399306A1

  公开（公告）日：2018-11-07

  Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.

  用于生物传感器的装置，该生物传感器包括多检测点阵列，该装置通过调节生物传感器电极附近的 pH 值或离子梯度，可用于调节（生物分子）探针或检测剂与生物中的相关分析物之间的结合相互作用。该装置提供的生物传感器更准确、更可靠，其结果的重现性也更高。此外，还提供了更精确测量生物样本中相关分析物的分析方法。