生物素-PEG12-四氟苯酚酯

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 中文名称: 生物素-PEG12-四氟苯酚酯
• 英文名称: biotin-dPEG₁₂-OTFP ester
• 英文别名: Biotin-PEG12-TFP ester；(2,3,5,6-tetrafluorophenyl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• 化学式: C₄₃H₆₉F₄N₃O₁₆S
• 分子量: 992.091
• InChiKey: YQTIPJSYUMZZNU-XRBIJUOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  67
• 可旋转键数：
  46
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  233
• 氢给体数：
  3
• 氢受体数：
  21

反应信息

• 作为反应物：
  描述：

  生物素-PEG12-四氟苯酚酯 、 以 二氯甲烷 为溶剂， 以21 %的产率得到
  参考文献：
  名称：

  [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR CELL-SPECIFIC PHARMACOLOGY
  [FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES DE PHARMACOLOGIE SPÉCIFIQUE À UNE CELLULE

  摘要：

  Disclosed herein are compounds that have improved cellular specificity. The compounds have linkers and other moieties that can both aid in cellular specificity and that can attach functional groups to a target cell. The compounds can be used, e.g., in methods of modulating, detecting, and labeling of proteins and cells. An example method includes the compound forming a covalent bond with a dehalogenase variant.

  公开号：

  WO2023225369A1

文献信息

• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR CELL-SPECIFIC PHARMACOLOGY<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES DE PHARMACOLOGIE SPÉCIFIQUE À UNE CELLULE
  申请人：[en]DUKE UNIVERSITY

  公开号：WO2023225369A1

  公开（公告）日：2023-11-23

  Disclosed herein are compounds that have improved cellular specificity. The compounds have linkers and other moieties that can both aid in cellular specificity and that can attach functional groups to a target cell. The compounds can be used, e.g., in methods of modulating, detecting, and labeling of proteins and cells. An example method includes the compound forming a covalent bond with a dehalogenase variant.