tert-butyl-1'-[4-(methylsulfinyl)phenyl]-4,4'-bipiperidine-1-carboxylate | 1034824-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl-1'-[4-(methylsulfinyl)phenyl]-4,4'-bipiperidine-1-carboxylate
• 英文别名: tert-butyl 1'-[4-(methylsulfinyl)phenyl]-4,4'-bipiperdine-1-carboxylate；Tert-butyl 4-(1-(4-(methylsulfinyl)phenyl)piperidin-4-yl)piperidine-1-carboxylate；tert-butyl 4-[1-(4-methylsulfinylphenyl)piperidin-4-yl]piperidine-1-carboxylate
• CAS: 1034824-91-3
• 化学式: C₂₂H₃₄N₂O₃S
• 分子量: 406.59
• InChiKey: WGIPWFWDEXLPAV-UHFFFAOYSA-N

物化性质

• 沸点：
  563.4±50.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  69.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl-1'-[4-(methylthio)phenyl]-4,4'-bipiperidine-1-carboxylate 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 tert-butyl-1'-[4-(methylsulfinyl)phenyl]-4,4'-bipiperidine-1-carboxylate
  参考文献：
  名称：

  WO2008/76243

  摘要：

  公开号：

文献信息

• ETHYLENE TETRAMERIZATION CATALYST SYSTEMS AND METHOD FOR PREPARING 1-OCTENE USING THE SAME
  申请人：Han Taek Kyu

  公开号：US20100137669A1

  公开（公告）日：2010-06-03

  Disclosed herein is a method of preparing 1-octene at high activity and high selectivity while stably maintaining reaction activity by tetramerizing ethylene using a chromium-based catalyst system comprising a transition metal or a transition metal precursor, a cocatalyst, and a P—C—C—P backbone structure ligand represented by (R 1 )(R 2 )P—(R 5 )CHCH(R 6 )—P(R 3 )(R 4 ).

  本文揭示了一种利用铬基催化剂体系通过四聚乙烯制备1-辛烯，在保持高活性和高选择性的同时稳定维持反应活性的方法，该催化剂体系包括过渡金属或过渡金属前驱体、共催化剂和由(R1)(R2)P—(R5)CHCH(R6)—P(R3)(R4)表示的P—C—C—P骨架结构配体。
• BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Wood Harold B.

  公开号：US20100029688A1

  公开（公告）日：2010-02-04

  Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式I的双哌啶化合物，可用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂也包括在内。这些化合物是G蛋白偶联受体GPR-119的激动剂。
• ACYL BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Wood Harold B.

  公开号：US20100075987A1

  公开（公告）日：2010-03-25

  Bipiperidyl compounds of the formula: (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式子为(I)的双哌啶类化合物，用于治疗或预防2型糖尿病和类似疾病。同时包括药用可接受的盐和溶剂。这些化合物可作为G蛋白偶联受体GPR-119的激动剂。
• BIPIPERIDINYL COMPOUNDS, COMPOSITIONS, CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：WOOD HAROLD B.

  公开号：US20120178681A1

  公开（公告）日：2012-07-12

  Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式I的双哌啶化合物，可用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂也包括在内。这些化合物可用作G蛋白偶联受体GPR-119的激动剂。
• Ethylene tetramerization catalyst system and method for preparing 1-octene using the same
  申请人：SK INNOVATION CO., LTD.LU

  公开号：US10131590B2

  公开（公告）日：2018-11-20

  Disclosed herein is a method of preparing 1-octene at high activity and high selectivity while stably maintaining reaction activity by tetramerizing ethylene using a chromium-based catalyst system comprising a transition metal or a transition metal precursor, a cocatalyst, and a P—C—C—P backbone structure ligand represented by (R1)(R2)P—(R5)CHCH(R6)—P(R3)(R4).

  本文公开了一种利用铬基催化剂体系制备 1-辛烯的方法，该催化剂体系由过渡金属或过渡金属前体、助催化剂以及由 (R1)(R2)P-(R5)CHCH(R6)-P(R3)(R4) 表示的 P-C-C-P 主干结构配体组成，通过乙烯四聚合，在稳定保持反应活性的同时实现高活性和高选择性。