6-methoxy-3-methyl-1,3,5-triazine-2,4-dione | 75465-41-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6-methoxy-3-methyl-1,3,5-triazine-2,4-dione
• 英文别名: 6-methoxy-3-methyl-1H-1,3,5-triazine-2,4-dione
• CAS: 75465-41-7
• 化学式: C₅H₇N₃O₃
• 分子量: 157.129
• InChiKey: NCFZUAYNWWAYFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,6-二甲氧基-1,3,5-三嗪-2(1H)-酮 以 重水 为溶剂， 生成 6-methoxy-3-methyl-1,3,5-triazine-2,4-dione
  参考文献：
  名称：

  Optimized triazine-mediated amidation for efficient and controlled functionalization of hyaluronic acid

  摘要：

  Triazine-based coupling agents have the potential to replace carbodiimides in the functionalization of hyaluronic acid (HA) giving derivatives with high degrees of substitution (DS) under mild conditions with excellent efficiency. Kinetics of the triazine-mediated amidation of HA in aqueous solution were investigated to understand the reaction mechanism and the role of the amine reagent. The DS decreased with increasing basicity of the amine. The water soluble coupling agent was stable under the reaction conditions (t(1/2)=10 days) in the absence of amines. The activation of HA proceeded quantitatively. The stoichiometry of amine was the limiting factor in the substitution. Functional HA derivatives with DS up to 55% were obtained by the triazine-mediated amidation. They were used successfully to prepare well-defined HA conjugates via the maleimide-thiol and the azide-alkyne "click" reactions. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2014.04.012

文献信息

• Perronnett, Jacques; Taliani, Laurent, Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 673 - 678
  作者：Perronnett, Jacques、Taliani, Laurent

  DOI：——

  日期：——
• PERRONNET J.; TALIANI L., J. HETEROCYCL. CHEM., 1980, 17, NO 4, 673-678
  作者：PERRONNET J.、 TALIANI L.

  DOI：——

  日期：——