2-hydroxy-3,6-dimethoxycarbonyl naphthalene | 183962-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-hydroxy-3,6-dimethoxycarbonyl naphthalene
• 英文别名: 2-hydroxy-3,6-dimethoxycarbonylnaphthalene；2-Hydroxy-3,6-di-methoxycarbonylnaphthalene；dimethyl 3-hydroxynaphthalene-2,7-dicarboxylate
• CAS: 183962-76-7
• 化学式: C₁₄H₁₂O₅
• 分子量: 260.246
• InChiKey: HCKPCMVRFZUDDU-UHFFFAOYSA-N

物化性质

• 沸点：
  399.2±22.0 °C(Predicted)
• 密度：
  1.315±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-hydroxy-3,6-dimethoxycarbonyl naphthalene 在 copper(l) chloride 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 48.0h， 生成 1,1'-bis(2-hydroxy-3,6-dimethoxycarbonyl naphthalene)
  参考文献：
  名称：

  EP1380564

  摘要：

  公开号：
• 作为产物：
  描述：

  7-methyl-3-hydroxy-2-naphthoic acid 在 4-二甲氨基吡啶 、 硫酸 、 palladium diacetate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 甲苯 为溶剂， 生成 2-hydroxy-3,6-dimethoxycarbonyl naphthalene
  参考文献：
  名称：

  MRGPRX2 ANTAGONIST FOR THE TREATMENT OF PSEUDO ALLERGIC REACTIONS

  摘要：

  Compounds that have antiallergic and/or anti-inflammatory properties and methods of making thereof are disclosed. These compounds can block MMRGPRX2 and prevent or reduce mast cells activation. Pharmaceutical formulations in a unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical formulations may include one or more active agents in addition to the compounds, such as one or more additional antiallergic and/or anti-inflammatory agents. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating pseudo allergic reactions, pseudo allergic diseases, and/or pseudo inflammatory diseases, or treating or ameliorating one or more symptoms associated with a pseudo allergic reaction, a pseudo allergic disease, and/or a pseudo inflammatory disease in a subject are also disclosed.

  公开号：

  US20220401435A1

文献信息

• Naphthol derivatives and process for producing the same
  申请人：Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo

  公开号：US05786523A1

  公开（公告）日：1998-07-28

  A naphthol derivative represented by the general formula (I) \x9bwherein Y and Y' indicate --(CONH).sub.n --X or --COR; X is a phenyl group, a naphthyl group, an anthraquinonyl group, a benzimidazolonyl group or a carbazolyl group; R is a hydroxyl group, an alkoxy group having 1 to 6 carbon atoms, a halogen atom, a benzyloxy group, a phenyloxy group or a phenacyloxy group; R.sub.2 is a hydrogen atom, an alkaline metal, an alkyl group having 1 to 6 carbon atoms, an acyl group having 1 to 6 carbon atoms or a phenylalkyl group; Z is a group selected from the group consisting of a hydrogen atom, a halogen atom, a nitro group, a nitroso group and an amino group (Z may be substituted on any ring of the naphthalene ring); and n is an integer of 1 or 2; provided that R.sub.2 and Z do not simultaneously indicate a hydrogen atom when both R simultaneously indicate a hydroxyl group!, and a process for producing the same. This naphthol derivative can be used as raw materials for synthesis, such as dyes, pigments, photosensitive materials and the like. ##STR1##

  一种由通式（I）表示的萘酚衍生物，其中Y和Y'表示--(CONH).sub.n--X或--COR；X是苯基、萘基、蒽醌基、苯并咪唑基或咔唑基；R是羟基、具有1至6个碳原子的烷氧基、卤素原子、苄氧基、苯氧基或苯乙酰氧基；R.sub.2是氢原子、碱金属、具有1至6个碳原子的烷基、具有1至6个碳原子的酰基或苯基烷基；Z是从氢原子、卤素原子、硝基、亚硝基和氨基（Z可以取代萘环的任何环上）组成的群中选择的群；n是1或2的整数；条件是当R同时表示羟基时，R.sub.2和Z不同时表示氢原子！以及其制备方法。这种萘酚衍生物可用作合成的原料，如染料、颜料、感光材料等。
• Compounds
  申请人：Kabushiki Kaisha Ueno Seiyaku Oyo Kenkujo

  公开号：US06284924B1

  公开（公告）日：2001-09-04

  A novel compound represented by the general formula (1) or salts thereof. The compound is useful as a structural component of polymers such as polyesters and polyamides. The compound wherein Y1, Y2, Y3, and/or Y4 are carboxy groups is especially useful as a structural component of a liquid crystal polymer with improved weld strength and anisotropy.

  一种由一般式（1）表示的新化合物或其盐。该化合物可作为聚酯和聚酰胺等聚合物的结构组分。其中Y1、Y2、Y3和/或Y4为羧基的化合物尤其适用于液晶聚合物的结构组分，具有改善的焊接强度和各向异性。
• NAPHTHOL DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
  申请人：KABUSHIKIKAISHA UENO SEIYAKU OYO KENKYUJO

  公开号：EP0765858A1

  公开（公告）日：1997-04-02

  A naphthol derivative represented by the general formula (I) [wherein Y and Y' indicate -(CONH)n-X or -COR; X is a phenyl group, a naphthyl group, an anthraquinonyl group, a benzimidazolonyl group or a carbazolyl group; R is a hydroxyl group, an alkoxy group having 1 to 6 carbon atoms, a halogen atom, a benzyloxy group, a phenyloxy group or a phenacyloxy group; R2 is a hydrogen atom, an alkaline metal, an alkyl group having 1 to 6 carbon atoms, an acyl group having 1 to 6 carbon atoms or a phenylalkyl group; Z is a group selected from the group consisting of a hydrogen atom, a halogen atom, a nitro group, a nitroso group and an amino group (Z may be substituted on any ring of the naphthalene ring); and n is an integer of 1 or 2; provided that R2 and Z do not simultaneously indicate a hydrogen atom when both R simultaneously indicate a hydroxyl group], and a process for producing the same. This naphthol derivative can be used as raw materials for synthesis, such as dyes, pigments, photosensitive materials and the like.

  通式(I)代表的萘酚衍生物[其中Y和Y'表示-(CONH)n-X或-COR；X是苯基、萘基、蒽醌基、苯并咪唑基或咔唑基；R 是羟基、1 至 6 个碳原子的烷氧基、卤素原子、苄氧基、苯氧基或苯乙氧基； R2 是氢原子、碱金属、1 至 6 个碳原子的烷基、1 至 6 个碳原子的酰基或苯基烷基；Z 是选自氢原子、卤素原子、硝基、亚硝基和氨基（Z 可在萘环的任何环上被取代）的基团；以及 n 是 1 或 2 的整数；条件是当两个 R 同时表示羟基时，R2 和 Z 不同时表示氢原子]，以及生产该衍生物的工艺。这种萘酚衍生物可用作染料、颜料、感光材料等合成原料。
• TONING AGENT
  申请人：KABUSHIKIKAISHA UENO SEIYAKU OYO KENKYUJO

  公开号：EP1043364A1

  公开（公告）日：2000-10-11

  A toning agent for an azo pigment, an azo pigment with a modified tone, and process for preparing the same are provided. 2-hydroxynaphthalene-3,6-dicarboxylic acid or a derivative thereof is admixed with a primary coupler component for an azo pigment and the mixed coupler composition and an aromatic diazonium are coupled.

  本发明提供了一种偶氮颜料的调色剂、一种具有改良色调的偶氮颜料及其制备工艺。 将 2-羟基萘-3,6-二羧酸或其衍生物与偶氮颜料的主偶联剂成分混合，并将混合偶联剂成分和芳香族重氮鎓偶联。
• NOVEL COMPOUNDS
  申请人：KABUSHIKIKAISHA UENO SEIYAKU OYO KENKYUJO

  公开号：EP1095930A1

  公开（公告）日：2001-05-02

  A novel compound represented by the general formula (1) or salts thereof. The compound is useful as a structural component of polymers such as polyesters and polyamides. The compound wherein Y1, Y2, Y3, and/or Y4 are carboxy groups is especially useful as a structural component of a liquid crystal polymer with improved weld strength and anisotropy.

  由通式（1）代表的新型化合物 或其盐类。该化合物可用作聚合物（如聚酯和聚酰胺）的结构成分。其中 Y1、Y2、Y3 和/或 Y4 为羧基的化合物尤其可用作液晶聚合物的结构成分，从而提高焊接强度和各向异性。