1-(4-methylphenyl)-2-phenylethan-1-amine | 30275-32-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(4-methylphenyl)-2-phenylethan-1-amine
• 英文别名: 2-phenyl-1-(p-tolyl)ethan-1-amine；rac-β-Phenyl-α-(p-tolyl)-ethylamin；1-Amino-1-(4-methyl-phenyl)-2-phenyl-aethan；1-(4-Tolyl)-2-phenyl-aethylamin；β-Phenyl-α(p-tolyl)ethylamin (rac.)；l-α-(p-tolyl)-β-phenylethylamine；β-phenyl-α-(p-tolyl)ethylamine；1-(4-methyl-phenyl)-2-phenyl-ethylamine；2-phenyl-1-p-tolyl-ethylamine；I+/--(4-Methylphenyl)benzeneethanamine；1-(4-methylphenyl)-2-phenylethanamine
• CAS: 30275-32-2
• 化学式: C₁₅H₁₇N
• mdl: MFCD00134666
• 分子量: 211.307
• InChiKey: AZJLZOVPJNPLGE-UHFFFAOYSA-N

物化性质

• 沸点：
  173-175 °C(Press: 10 Torr)
• 密度：
  1.037±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(2-氯乙基)吗啉 、 1-(4-methylphenyl)-2-phenylethan-1-amine 生成 N-(2-Morpholino-ethyl)-1-p-tolyl-2-phenylethylamin
  参考文献：
  名称：

  Zaheer,S.H. et al., Justus Liebigs Annalen der Chemie, 1966, vol. 691, p. 55 - 60

  摘要：

  DOI：
• 作为产物：
  描述：

  4-methylstilbene 在 对苯二腈 、 氨 作用下， 以 水 、 乙腈 、 苯 为溶剂， 反应 20.0h， 生成 1-(4-methylphenyl)-2-phenylethan-1-amine 、 (S)-1-苯基-2-对甲基苯乙胺
  参考文献：
  名称：

  Regiochemistry on photoamination of stilbene derivatives with ammonia via electron transfer

  摘要：

  The regiochemistry of photoamination of 1,2-diarylethene (1) with ammonia in the presence of p-dicyanobenzene (DCNB) has been investigated. The photoamination of stilbene and p,p'-dimethoxystilbene gave 1-amino-1,2-diphenylethane and 1-amino-1,2-bis(p-methoxyphenyl)ethane, respectively. The photoamination of unsymmetric 1-aryl-2-phenylethene having an alkoxy group on the para position occurred selectively to give 1-amino-2-aryl-1-phenylethane. On the other hand, the photoamination of 1-aryl-2-phenylethene having a methyl and chloro group on the para position or methoxy group on the meta and ortho positions gave both 1-amino-2-aryl-1-phenylethane and 1-amino-1-aryl-2-phenylethane. The regiochemistry is related with the distribution of positive charge in the cation radicals of 1 generated from photochemical electron transfer to DCNB.

  DOI：

  10.1021/jo00031a010

文献信息

• Alkaline-Metal-Catalyzed One-Pot Aminobenzylation of Aldehydes with Toluenes
  作者：Guoqing Liu、Patrick J. Walsh、Jianyou Mao

  DOI：10.1021/acs.orglett.9b02737

  日期：2019.11.1

  A novel and easily accessible MN(SiMe3)2 (M = Li or Na)/Cs2CO3 co-catalyzed benzylation of in situ generated N-(trimethylsilyl) aldimines with toluene derivatives has been successfully developed. The catalyst exhibits high chemoselectivity for deprotonation of toluenes at the benzylic position. The utility of this system is exemplified by the one-pot synthesis of a diverse array of bioactive 1,2-diarylethylamines

  已成功开发了一种新颖且易于使用的MN（SiMe 3）2（M = Li或Na）/ Cs 2 CO 3催化原位生成的N-（三甲基甲硅烷基）亚胺与甲苯衍生物的苄基化反应。该催化剂对苄基位置的甲苯去质子表现出高化学选择性。一锅合成具有优异效率和宽泛的官能团耐受性的各种生物活性1,2-二芳基乙胺的例子说明了该系统的实用性。
• THERAPEUTIC FLUOROETHYL UREAS
  申请人：Chow Ken

  公开号：US20070270498A1

  公开（公告）日：2007-11-22

  Compounds of the formula or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein A and B are as described herein, are useful for treating conditions afflicting mammals.

  该公式化合物或其药用盐或其互变异构体，其中A和B如本文所述，可用于治疗影响哺乳动物的疾病。
• Method for producing and optically active 2,2-dimethylcyclopropanecarboxylic acid
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0093511A1

  公开（公告）日：1983-11-09

  A method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid useful as an intermediate for dehydropeptidase 1 inhibitors, medicines and agricultural chemicals, which comprises reacting an optically active diphenylethylamine represented by the formula, wherein R1 and R2 are a hydrogen atom or a lower alkyl group, with 2,2-dimethylcyclopropanecarboxylic acid in a solvent to achieve the optical purification of said acid.

  一种生产具有光学活性的 2,2-二甲基环丙烷羧酸的方法，可用作脱氢肽酶 1 抑制剂、药物和农用化学品的中间体，该方法包括将具有光学活性的二苯基乙胺与 2,2-二甲基环丙烷羧酸反应，二苯基乙胺的化学式为 其中 R1 和 R2 为氢原子或低级烷基，与 2,2-二甲基环丙烷羧酸在溶剂中反应，以实现所述酸的光学纯化。
• Method of obtaining optically active half esters
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0092194A1

  公开（公告）日：1983-10-26

  A method of separating optically active half esters comprising optically resolving a mixture of a (4S,5R)-1,3-dibenzyl-5-alkoxy or alkenyloxycarbonyl-2-oxoimidazolidine-4-carboxylic acid and a (4R,5S)-1,3-dibenzyl-5-alkoxy or alkenyloxycarbonyl-2-oxoimidazolidine-4-carboxylic acid, each being represented by the formula (I): wherein R1 is an alkyl group or an alkenyl group, each having 1 to 5 carbon atoms; Bzl is a benzyl group; * indicates an asymmetric carbon atom; and the 4- and 5-positions are a cis-configuration, using an optically active d- or 1-amine represented by the formula (II): wherein R2 and R3 are each a hydrogen atom, a halogen atom or methyl group; and indicates an asymmetric carbon atom; and the eforementioned half esters are disclosed. A method for the preparation of an optically active (4S,5R)-cis-1,3-dibenzyl-5-methoxy- or ethoxycarbonyl-2-oxoimidazolidine-4-carboxylic acid (la') or (4R,5S)-cis-1,3-dibenzyl-5-methoxy- or ethoxycarbonyl-2-oxoimidazolidine-4-carboxylic acid (Ib'), comprising preferentially crystallizing (Ia') or (Ib') from a supersaturated solution where (la' ) and (Ib') are copresent in the presence of crystals of the same type of optically active half ester as that to be crystallized, is also disclosed.

  一种分离光学活性半酯的方法，包括光学解析(4S,5R)-1,3-二苄基-5-烷氧基或烯酰氧基羰基-2-氧代咪唑烷-4-羧酸和(4R,5S)-1,3-二苄基-5-烷氧基或烯酰氧基羰基-2-氧代咪唑烷-4-羧酸的混合物，各自由式(I)表示： 其中 R1 是烷基或烯基，各具有 1 至 5 个碳原子；Bzl 是苄基；* 表示不对称碳原子；4 位和 5 位为顺式构型，使用由式（II）表示的具有光学活性的 d- 或 1-胺： 其中 R2 和 R3 各为氢原子、卤素原子或甲基；且表示不对称碳原子；本发明公开了上述半酯。一种制备光学活性(4S,5R)-顺式-1,3-二苄基-5-甲氧基-或乙氧基羰基-2-氧代咪唑烷-4-羧酸(la')或(4R,5S)-顺式-1,3-二苄基-5-甲氧基-或乙氧基羰基-2-氧代咪唑烷-4-羧酸(Ib')的方法、本发明还公开了(Ia')或(Ib')从过饱和溶液中优先结晶的方法，其中(la')和(Ib')在与待结晶的光学活性半酯类型相同的晶体存在下共存。
• Convenient Access to Primary Amines by Employing the Barbier-Type Reaction of <i>N</i>-(Trimethylsilyl)imines Derived from Aromatic and Aliphatic Aldehydes
  作者：Ferenc Gyenes、Kathryn E. Bergmann、John T. Welch

  DOI：10.1021/jo971061r

  日期：1998.5.1

  A new versatile preparation of primary amines via benzylation of aromatic and aliphatic aldimines is described. Sonochemical and traditional methods for generation of the reactive intermediates are compared and contrasted. Competitive reactions were analyzed via free energy relationships to support the proposed alkylative mechanism.