2-amino-3-(2-naphthoyl)thiophene | 399043-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-amino-3-(2-naphthoyl)thiophene
• 英文别名: (2-Amino-3-thienyl)-2-naphthalenylmethanone；(2-aminothiophen-3-yl)-naphthalen-2-ylmethanone
• CAS: 399043-26-6
• 化学式: C₁₅H₁₁NOS
• 分子量: 253.324
• InChiKey: ZVMSCFDWUOVLPN-UHFFFAOYSA-N

物化性质

• 沸点：
  491.4±30.0 °C(Predicted)
• 密度：
  1.309±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-萘甲酸甲酯 在 sodium hydride 作用下， 以 乙醇 、 甲苯 、 mineral oil 为溶剂， 反应 30.17h， 生成 2-amino-3-(2-naphthoyl)thiophene
  参考文献：
  名称：

  An Efficient Synthesis of 2-Aminothiophenes via the Gewald Reaction Catalyzed by an N-Methylpiperazine-Functionalized Polyacrylonitrile Fiber

  摘要：

  A new N-methylpiperazine-functionalized polyacrylonitrile fiber has been developed to catalyze the Gewald reaction between 2,5-dihydroxy-1,4-dithiane and activated nitriles to afford 3-substituted 2-aminothiophenes in good to excellent yields (65-91%). Low catalyst loading (8.0 mol%), simple procedure, high yields, excellent recyclability, and reusability (up to 10 times with minimal loss of catalytic activity) are attractive features of this fiber catalyst.

  DOI：

  10.1055/s-0032-1316821

文献信息

• TRAUMA THERAPY
  申请人：Dobson Geoffrey Philip

  公开号：US20090324748A1

  公开（公告）日：2009-12-31

  The invention provides a method of reducing injury to cells, tissues or organs of a body following trauma by administering a composition to the body following trauma, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) a local anaesthetic. Also provided is a composition for reducing injury to cells, tissues or organs of a body following trauma including: (i) and (ii). The composition may be hypertonic.

  本发明提供了一种减少创伤后身体细胞、组织或器官受损的方法，包括在创伤后向身体注射一种组合物，其中包括：（i）一个钾通道开放剂或激动剂和/或腺苷受体激动剂；和（ii）一个局部麻醉剂。同时提供了一种用于减少创伤后身体细胞、组织或器官受损的组合物，包括（i）和（ii）。该组合物可以是高渗的。
• Improved tissue maintenance
  申请人：Hibernation Therapeutics Limited

  公开号：EP2471360A1

  公开（公告）日：2012-07-04

  The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.

  本发明提供了一种减少外科手术对组织、器官或细胞的损伤的方法，包括在灌注器官时施用一种组合物，该组合物包含钾离子通道开启剂/激动剂和/或腺苷受体激动剂（如腺苷）以及局麻药（如木质素）。
• Tissue maintenance
  申请人：Hibernation Therapeutics, A KF LLC

  公开号：US10251905B2

  公开（公告）日：2019-04-09

  The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.

  本发明提供了一种减少外科手术对组织、器官或细胞的损伤的方法，包括在灌注器官时施用一种组合物，该组合物包含钾离子通道开启剂/激动剂和/或腺苷受体激动剂（如腺苷）以及局麻药（如木质素）。
• Method for treating haemorrhage, shock and brain injury
  申请人：Hibernation Therapeutics, A KF, LLC

  公开号：US10786525B2

  公开（公告）日：2020-09-29

  The invention relates to a composition and method for increasing blood pressure, including a low pain or analgesic state or hypotensive anaesthesia in a subject that has suffered a life threatening hypotension or shock or reducing hypofusion in the whole body of a subject. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; and (ii) an antiarrhythmic agent or a local anaesthetic.

  本发明涉及一种组合物和方法，用于增加血压，包括使遭受危及生命的低血压或休克的受试者处于低痛或镇痛状态或低血压麻醉，或减少受试者全身的低灌注。该组合物包括：(i) 选自钾通道开放剂、钾通道激动剂和腺苷受体激动剂中至少一种的化合物；(ii) 抗心律失常剂或局部麻醉剂。
• Organ arrest, protection, preservation and recovery
  申请人：Dobson Phillip Geoffrey

  公开号：US20050202394A1

  公开（公告）日：2005-09-15

  The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia and a compound for reducing the uptake of water by a cell in the tissue. The present invention also realtes to the use of the composition accordng to the invention for controlling viability of a tissue.

  本发明涉及一种用于控制组织活力的组合物，包括一种钾通道开启剂或腺苷受体激动剂、一种用于诱导局部麻醉的化合物和一种用于减少组织中细胞摄取水分的化合物。本发明还涉及符合本发明的组合物在控制组织活力方面的用途。