6-(2,5-Dichlorothiophen-3-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde | 1012874-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并噻唑类
• 英文名称: 6-(2,5-Dichlorothiophen-3-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde
• CAS: 1012874-97-3
• 化学式: C₁₀H₆Cl₂N₂OS₂
• 分子量: 305.208
• InChiKey: FFOUHCGOYWOXKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  88.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(2,5-Dichlorothiophen-3-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde 、 肼甲酰亚胺酰胺一氯化氢 以 乙醇 为溶剂， 生成 2-[(E)-[6-(2,5-dichlorothiophen-3-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride
  参考文献：
  名称：

  New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogues¹

  摘要：

  The synthesis of new antitumor 6-substituted imidazothiazole guanylhydrazones is described. Moreover, a series of compounds with a different basic chain at the 5 position were prepared. Finally, the replacement of the thiazole ring in the imidazothiazole system was also considered. All the new compounds prepared were submitted to the NCI cell line screen for evaluation of their antitumor activity. A few selected compounds were submitted to additional biological studies concerning effects on the cell cycle, apoptosis, and mitochondria.

  DOI：

  10.1021/jm701246g
• 作为产物：
  描述：

  6-(2,5-Dichlorothiophen-3-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 以 氯仿 为溶剂， 生成 6-(2,5-Dichlorothiophen-3-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde
  参考文献：
  名称：

  New Antitumor Imidazo[2,1-b]thiazole Guanylhydrazones and Analogues¹

  摘要：

  The synthesis of new antitumor 6-substituted imidazothiazole guanylhydrazones is described. Moreover, a series of compounds with a different basic chain at the 5 position were prepared. Finally, the replacement of the thiazole ring in the imidazothiazole system was also considered. All the new compounds prepared were submitted to the NCI cell line screen for evaluation of their antitumor activity. A few selected compounds were submitted to additional biological studies concerning effects on the cell cycle, apoptosis, and mitochondria.

  DOI：

  10.1021/jm701246g

文献信息

• New Antitumor Imidazo[2,1-<i>b</i>]thiazole Guanylhydrazones and Analogues¹
  作者：Aldo Andreani、Silvia Burnelli、Massimiliano Granaiola、Alberto Leoni、Alessandra Locatelli、Rita Morigi、Mirella Rambaldi、Lucilla Varoli、Natalia Calonghi、Concettina Cappadone、Giovanna Farruggia、Maddalena Zini、Claudio Stefanelli、Lanfranco Masotti、Norman S. Radin、Robert H. Shoemaker

  DOI：10.1021/jm701246g

  日期：2008.2.1

  The synthesis of new antitumor 6-substituted imidazothiazole guanylhydrazones is described. Moreover, a series of compounds with a different basic chain at the 5 position were prepared. Finally, the replacement of the thiazole ring in the imidazothiazole system was also considered. All the new compounds prepared were submitted to the NCI cell line screen for evaluation of their antitumor activity. A few selected compounds were submitted to additional biological studies concerning effects on the cell cycle, apoptosis, and mitochondria.