N-(1,2-dimethylpropyl)-piperazine | 57184-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(1,2-dimethylpropyl)-piperazine
• 英文别名: 1-(3-Methylbutan-2-yl)piperazine
• CAS: 57184-42-6
• 化学式: C₉H₂₀N₂
• 分子量: 156.271
• InChiKey: QEYIMLBNNVXWJD-UHFFFAOYSA-N

物化性质

• 沸点：
  198.7±8.0 °C(Predicted)
• 密度：
  0.872±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [(9E,19E,21E)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl] acetate 、 N-(1,2-dimethylpropyl)-piperazine 、 1,4-二氧六环 生成 [(9E,19E,21E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[4-(3-methylbutan-2-yl)piperazin-1-yl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl] acetate
  参考文献：
  名称：

  BICKEL, H.;KUMP, W.

  摘要：

  DOI：

文献信息

• New Pyridinones and Isoquinolinones as Inhibitors of the Bromodomain BRD9
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180044335A1

  公开（公告）日：2018-02-15

  The present invention encompasses compounds of general formula (I) wherein the groups R 1 to R 9 , X 1 and X 2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, e.g. cancer, pharmaceutical preparations containing such compounds and their uses as a medicament.

  本发明涵盖了一般式（I）的化合物，其中基团R1至R9，X1和X2的含义如权利要求和说明书中所述。本发明的化合物适用于治疗由细胞过度或异常增殖所特征化的疾病，例如癌症，含有这种化合物的制药制剂以及它们作为药物的用途。
• ISOQUINOLINONE DERIVATIVES
  申请人：BROUGH Stephen John

  公开号：US20100099665A1

  公开（公告）日：2010-04-22

  The present invention relates to isoquinolinone derivatives of formula (I): wherein are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的异喹啉酮衍生物，其中定义如下；制备它们的方法，含有它们的制药组合物以及它们在治疗中的应用。
• BICKEL, H.;KUMP, W.
  作者：BICKEL, H.、KUMP, W.

  DOI：——

  日期：——
• ENANTIOMERICALLY PURE ADAMANTANE CARBOXAMIDES FOR THE TREATMENT OF FILOVIRUS INFECTION
  申请人：Arisan Therapeutics, Inc.

  公开号：US20210171521A1

  公开（公告）日：2021-06-10

  The compounds of the invention as shown by general structure I, as shown below, are effective in treating filovirus infections. X is selected from the group consisting of O and H; R 1 is selected from (C 6 to C 10 ) aryl and (C 2 to C 9 ) heteroaryl, and R 2 is selected from (C 1 to C 10 ) alkyl, (C 1 to C 10 ) alkenyl, (C 1 to C 10 ) alkynyl, (C 3 to C 10 ) cycloalkyl, and (C 5 to C 10 ) cycloalkenyl, and NR 3a R 3b is defined in the specification. These compounds are effective in treating filovirii infections including Ebolavirus and Marburg virus.
• US4005077A
  申请人：——

  公开号：US4005077A

  公开（公告）日：1977-01-25