(E)-2-(2-(3-fluorostyryl)phenyl)pyridine | 1085411-76-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-2-(2-(3-fluorostyryl)phenyl)pyridine
• 英文别名: 2-[2-[(E)-2-(3-fluorophenyl)ethenyl]phenyl]pyridine
• CAS: 1085411-76-2
• 化学式: C₁₉H₁₄FN
• 分子量: 275.325
• InChiKey: UAFDRXQCMOQFPL-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-苯基吡啶 、 1-乙炔基-3-氟苯 在 N-甲基吡咯烷酮 、 ruthenium trichloride 、 potassium carbonate 、 过氧化苯甲酰 作用下， 反应 6.0h， 以67%的产率得到(E)-2-(2-(3-fluorostyryl)phenyl)pyridine
  参考文献：
  名称：

  RuCl₃-Catalyzed Alkenylation of Aromatic C−H Bonds with Terminal Alkynes

  摘要：

  RuCl3-catalyzed regio- and/or stereoselective alkenylation reactions of a variety of arylpyridines proceeded efficiently with terminal alkynes or allylic compounds in the presence of benzoyl peroxide or benzoic acid.

  DOI：

  10.1021/ol802262r

文献信息

• Ruthenium-catalyzed Suzuki coupling of anilines with alkenyl borates via selective aryl C N bond cleavage
  作者：Jian-Xing Xu、Fengqian Zhao、Robert Franke、Xiao-Feng Wu

  DOI：10.1016/j.catcom.2020.106009

  日期：2020.6

  Herein, we developed a new ruthenium(0)-catalyzed Suzuki-coupling of N,N-dimethyl-2-(pyridin-2-yl) anilines with alkenyl borates to synthesize 2-phenylolefins via the cleavage of neutral aryl C-N bond. In the absence of ligand and additives, by using pyridine as the directing group, the desired 2-phenylolefins were obtained in good to excellent yields with high stereoselectivity (E/Z > 20:1).
• RuCl₃-Catalyzed Alkenylation of Aromatic C−H Bonds with Terminal Alkynes
  作者：Kai Cheng、Bangben Yao、Jinlong Zhao、Yuhong Zhang

  DOI：10.1021/ol802262r

  日期：2008.11.20

  RuCl3-catalyzed regio- and/or stereoselective alkenylation reactions of a variety of arylpyridines proceeded efficiently with terminal alkynes or allylic compounds in the presence of benzoyl peroxide or benzoic acid.